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Granisetron Alleviates Alzheimer's Disease Pathology in TgSwDI Mice Through Calmodulin-Dependent Protein Kinase II/cAMP-Response Element Binding Protein Pathway

Journal of Alzheimer's Disease : JAD

Oct 29, 2019

Sweilem B Al RihaniAmal Kaddoumi

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Abstract

Alzheimer's disease (AD) is characterized by a compromised blood-brain barrier (BBB) and disrupted intracellular calcium homeostasis in the brain. Therefore, rectifying the BBB integrity and restoring calcium homeostasis could provide an effective strategy to treat AD. Recently, we deve...read more

Mentioned in this Paper

Alzheimer's Disease
Blood - Brain Barrier Anatomy
Brain
Inflammation
Laboratory mice
Mice, Transgenic
Pathology
Protein Binding
Granisetron
Intracellular
1
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Granisetron Alleviates Alzheimer's Disease Pathology in TgSwDI Mice Through Calmodulin-Dependent Protein Kinase II/cAMP-Response Element Binding Protein Pathway

Journal of Alzheimer's Disease : JAD

Oct 29, 2019

Sweilem B Al RihaniAmal Kaddoumi

PMID: 31683487

DOI: 10.3233/jad-190849

Abstract

Alzheimer's disease (AD) is characterized by a compromised blood-brain barrier (BBB) and disrupted intracellular calcium homeostasis in the brain. Therefore, rectifying the BBB integrity and restoring calcium homeostasis could provide an effective strategy to treat AD. Recently, we deve...read more

Mentioned in this Paper

Alzheimer's Disease
Blood - Brain Barrier Anatomy
Brain
Inflammation
Laboratory mice
1

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