Granistron and dexamethasone provide more improved prevention of postoperative emesis than granisetron alone in children

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Y FujiiH Toyooka

Abstract

Dexamethasone decreases chemotherapy-induced emesis when added to antiemetic regimens. This study was designed to compare the effectiveness of granisetron and dexamethasone with granisetron alone in the prevention of post-operative vomiting after strabismus repair, tonsillectomy with or without adenoidectomy in children. In a randomized, double-blind study, 60 healthy children, 4-10 yr of age, received either granisetron 40 micrograms.kg-1 and saline (Group S) or granisetron 40 micrograms.kg-1 and dexamethasone 4 mg (Group D) iv immediately after the induction of anaesthesia. All subjects received anaesthetics consisting of sevoflurane and nitrous oxide in oxygen Postoperative pain was treated with acetaminophen pr or pentazocine iv. Postoperatively, during the first 24 hr after anaesthesia, the frequencies of retching and vomiting, and the incidence of adverse events were recorded by nursing staff. There were no differences between the treatment groups with regard to demographics, surgical procedure, anaesthetic administered or analgesics used for postoperative pain. The frequency of the symptoms was 27% and 7% in Groups S and D, respectively (P < 0.05). The incidence of adverse events was comparable in the two groups. The pro...Continue Reading

References

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Citations

Jan 8, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Charles J Coté, Stephen H Sheldon
Oct 23, 2002·Paediatric Drugs·Pasquale De Negri, Giorgio Ivani
Oct 6, 2009·International Journal of Pediatric Otorhinolaryngology·Murat KaramanArman Tek
Mar 11, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·G Orliaguet
Oct 24, 2003·International Anesthesiology Clinics·Ashraf S Habib, Tong J Gan
Aug 13, 2011·The Cochrane Database of Systematic Reviews·David L StewardJareen Meinzen-Derr
Jul 18, 2017·The Cochrane Database of Systematic Reviews·John Carlisle, Carl A Stevenson
Nov 19, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Chernkwan TitirungruangP Hirunwiwatkul

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