Granular cell tumor of the appendix: a new case and review of the literature

SpringerPlus
Luca RoncatiAldo Rossi

Abstract

Granular cell tumor (GCT) is a rare and usually benign lesion of neural / schwannian origin, most frequently found in middle-age women. The appendicular involvement is extremely rare: in over half a century only twelve cases have been reported in the literature, the patients living in America and Europe. Hitherto, no cases are documented from Africa, Asia and Oceania and no cases of malignant GCTs of the appendix have been reported. Most patients were diagnosed preoperatively as having acute appendicitis, whereas in three patients the tumor was incidentally detected during major abdominal surgery. The GCTs were equally distributed between mid-appendix and tip, where lymphoid tissue is more abundant and the anatomical nerve supply is progressively reduced. Moreover, the appendix surrounding the GCTs is characterized by the presence of chronic inflammatory cells (histiocytes, plasmocytes, eosinophils, mastocytes) and, therefore, a chronic inflammation of the appendix may be an antecedent condition favouring the appearance of GCTs. The GCT of the appendix appears so to be a lesion that reflects local reactive changes in the neural / schwannian cells, rather than being a genuine neoplasm. We describe the smallest GCT of the appendi...Continue Reading

References

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Citations

Dec 8, 2015·Virchows Archiv : an International Journal of Pathology·Isidro MachadoAntonio Llombart-Bosch
Sep 30, 2014·Archives of Dermatological Research·Simona GurzuIoan Jung
Mar 16, 2017·The American Journal of Surgical Pathology·Mary Ellen RiffleMirna Chehade
Jun 1, 2020·Digestive Diseases and Sciences·Yongsheng ShiEnqiang Linghu
Jan 13, 2021·Digestive Diseases and Sciences·Nico PaganoGilberto Poggioli
May 23, 2021·Veterinary Medicine and Science·Alejandro OrorbiaYvonne Espada
Jun 10, 2021·Diagnostic Pathology·Deepti ReddiPaul E Swanson

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Methods Mentioned

BETA
surgical resection

Software Mentioned

Monaco

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