Granular cell tumor of the infundibulum: a systematic review of MR-radiography, pathology, and clinical findings

Journal of Neuro-oncology
Jessica B PolasekEkkehard M Kasper

Abstract

Granular cell tumors (GCTs) of the infundibulum are rare in practice and literature, resulting in a lack of evidence-based standard of care. We present two characteristic cases from our institution and perform a systematic review of the existing literature to further elucidate the presentation of this tumor and guide management. A systematic literature search was conducted according to PRISMA guidelines, yielding 42 total individual reported GCTs suitable for evaluation. Available clinical presentation, magnetic resonance imaging (MRI) characteristics, pathology, surgical approaches, and outcomes were charted. We measured frequencies of clinical characteristics and performed an outcome comparison of open versus endoscopic surgical treatment. In this pooled dataset, GCT incidence was higher in females than males (3:1). Clinical presentation peaked in the fourth decade with tumor-related symptoms. MRI appearance was characterized by T1 isointensity (50%) and T2 hypointensity or isointensity (52%) with gadolinium contrast enhancement (74%). Histopathology demonstrated positive staining for PAS, PAS-D, S100, CD68, and TTF1. In a simple uncontrolled analysis, patients who underwent endoscopic surgery experienced more symptom improve...Continue Reading

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Citations

Oct 18, 2019·Pituitary·Abdul-Kareem AhmedTimothy R Smith
Mar 14, 2019·Reviews in Endocrine & Metabolic Disorders·Fernando Guerrero-PérezCarles Villabona
Dec 16, 2021·Journal of Neurological Surgery. Part A, Central European Neurosurgery·Sandeep KandregulaArivazhagan Arimappamagan

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