Granular Cell Tumor of the Neurohypophysis: 3 Cases and a Systematic Literature Review of 98 Cases

World Neurosurgery
Yi ZhangYong Yao

Abstract

Granular cell tumors (GCTs) of the neurohypophysis are rare neoplastic diseases of the pituitary. Because of the rare nature of the disease, previous descriptions have been limited to single-case studies, small series, or simple reviews. We reported 3 cases in our medical center and systematically reviewed 98 cases who met inclusion criteria. Data were gathered on different aspects of GCTs' characteristics, including demographics, clinical features, laboratory features, histological features, immunocytochemical features, radiologic features, and treatment to elucidate any associations useful in determining pathogenesis and appropriate treatment. Female sex was significantly associated with GCTs (P < 0.001). The most common presenting symptom and tentative diagnosis were ophthalmologic defects in 61.2% and pituitary adenoma preoperatively in 18.4%, respectively. Most neurohypophysial GCTs possess immunopositivity for S-100 protein (59.1%, 26/44) and negative staining for glial fibrillary acidic protein (69.8%, 30/43). These findings lend strong support to the suggestion that tumors probably remain in the transitional cell type. To our knowledge, our systematic review presents the largest number of symptomatic cases ever enumerat...Continue Reading

Citations

Oct 18, 2019·Pituitary·Abdul-Kareem AhmedTimothy R Smith
Mar 14, 2019·Reviews in Endocrine & Metabolic Disorders·Fernando Guerrero-PérezCarles Villabona
Nov 27, 2020·Endocrinología, Diabetes Y Nutrición·Beatriz López-MuñozAntonio Picó Alfonso
Dec 16, 2021·Journal of Neurological Surgery. Part A, Central European Neurosurgery·Sandeep KandregulaArivazhagan Arimappamagan

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