PMID: 8609127Apr 1, 1996Paper

Granular histiocytosis of pelvic lymph nodes following total hip arthroplasty. The presence of wear debris, cytokine production, and immunologically activated macrophages

The Journal of Bone and Joint Surgery. American Volume
D G HicksR J O'Keefe

Abstract

Infiltration of regional lymph nodes by macrophages has been demonstrated after total joint arthroplasty. Although lymph nodes regulate the immune response, neither cytokine production nor the degree of immunological activation of cells within these nodes after total joint arthroplasty has been investigated. Pelvic lymph nodes were obtained from five patients who had had a total of eleven arthroplasties in seven hips three to twenty years before a pelvic staging procedure for adenocarcinoma (of the prostate in four patients and of the endometrium in one). All lymph nodes had polyethylene or metal debris as well as effacement of the normal nodal architecture by a histiocytic infiltrate. These changes were bilateral in the patients who had had an arthroplasty of one hip. Analysis of specimens from pelvic lymph nodes on the side of the involved hip demonstrated intense immunohistochemical staining of histiocytes for the major histocompatibility complex class-II antigen HLA-DR, a marker of histiocyte immune activation. In contrast, staining was absent in specimens from the contralateral lymph nodes as well as in those from seven patients who had had a prostatectomy but not a hip arthroplasty. Immunohistochemical staining for interl...Continue Reading

References

Jan 1, 1975·Virchows Archiv. A, Pathological Anatomy and Histology·K HeilmannK A Brinkman
Sep 1, 1992·American Journal of Obstetrics and Gynecology·E R NorwitzP M Starkey
Jan 1, 1992·The Journal of Bone and Joint Surgery. British Volume·N A AthanasouC J Bulstrode
Jan 1, 1991·Annual Review of Immunology·F M Brodsky, L E Guagliardi
Dec 1, 1989·The American Journal of Surgical Pathology·M H GrayA Hsu
Mar 1, 1988·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Z R ShiY S Kim
Aug 1, 1988·The Journal of Bone and Joint Surgery. British Volume·W J GillespieP M Ryan
May 1, 1986·The Journal of Experimental Medicine·E K BayneJ A Schmidt
Jun 1, 1993·The Journal of Bone and Joint Surgery. American Volume·S M HorowitzA H Burstein
Jun 1, 1993·The Journal of Bone and Joint Surgery. American Volume·D R HaynesD W Howie
Jun 1, 1993·The Journal of Bone and Joint Surgery. American Volume·W J MaloneyD J Schurman
Jan 1, 1993·The Journal of Bone and Joint Surgery. American Volume·T W BauerA H Wilde
Mar 1, 1993·American Journal of Clinical Pathology·J X O'Connell, A E Rosenberg

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Citations

Jun 10, 1998·Journal of Biomedical Materials Research·G A LundeenR D Bloebaum
Feb 11, 1999·The Journal of Bone and Joint Surgery. American Volume·T P Schmalzried, J J Callaghan
May 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S G KaarE M Greenfield
Aug 5, 2003·Clinical Orthopaedics and Related Research·Satoshi TakayanagiKenji Takagishi
Oct 24, 2006·Foot & Ankle International·Judith F BaumhauerMichael S Pinzur
Jan 26, 2013·Journal of Biomedical Materials Research. Part a·Sandra C P CachinhoJohn A Hunt
Dec 12, 2019·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Laura RubioAlba Hernández
Feb 24, 2001·Journal of Biomedical Materials Research·J A BainbridgeN Al-Saffar
Jan 6, 2001·Acta Orthopaedica Scandinavica·O RahbekK Søballe
Apr 13, 2000·The Journal of Bone and Joint Surgery. American Volume·R M UrbanM Peoc'h
Apr 21, 2012·Journal of Cutaneous Pathology·Daniel D MillerMeera Mahalingam
Jan 11, 2014·International Journal of Surgical Pathology·John K C Chan
Apr 1, 1996·The Journal of Bone and Joint Surgery. American Volume·T W Bauer
Jan 13, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A A RagabE M Greenfield
Apr 24, 2001·The Journal of Bone and Joint Surgery. American Volume·Y BiE M Greenfield
Mar 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Marius von KnochSean P Scully
Feb 22, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Edward M GreenfieldR Renee Van De Motter
Mar 16, 2000·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·E Ingham, J Fisher
Jul 16, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jan FritzHollis G Potter
Jan 22, 2011·Clinical Oral Implants Research·Allauddin SiddiqiWarwick J Duncan
Mar 19, 2013·Journal of Biomedical Materials Research. Part a·Ahmed El-GhannamLarry Cunningham
Feb 26, 2003·Journal of Biomedical Materials Research. Part a·Amarpal AroraStuart Goodman
Jun 6, 2006·Acta Orthopaedica·Mikael SundfeldtChristina Gretzer
Nov 20, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D R PedersenJ J Callaghan
Jan 5, 2006·Journal of Biomedical Materials Research. Part a·Gavin JellNajat Al-Saffar
Aug 1, 2020·PloS One·Evangelos DanopoulosJeanette M Rotchell
Feb 6, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christian LhotkaKarl Zweymüller
Feb 3, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·M ScottS Jani
Jan 6, 2021·Environment International·Antonio RagusaElisabetta Giorgini
Dec 15, 2020·The Science of the Total Environment·Gregory M ZarusR Steven Pappas
Nov 19, 2017·Seminars in Diagnostic Pathology·Caoimhe Egan, Elaine S Jaffe
May 23, 2017·Environmental Science & Technology·Stephanie L Wright, Frank J Kelly
Sep 3, 2021·Journal of Agricultural and Food Chemistry·Qingrun LiuYunfei Xie

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