PMID: 12753175May 20, 2003Paper

Granular parakeratosis: a case report and literature review

Journal of Cutaneous Pathology
Christopher A WallaceO P Sangueza

Abstract

Granular parakeratosis is suspected to result from an error in epidermal differentiation, leading to variably pruritic, hyperpigmented-to-erythematous patches and plaques. Characteristic histopathologic features include a thickened stratum corneum, compact parakeratosis with retention of keratohyalin granules, vascular proliferation, and ectasia. The pathogenesis of this entity is uncertain. We present a case of axillary granular parakeratosis and review the literature. The lesion showed a thickened stratum corneum with compact parakeratosis, slight epidermal hyperplasia, and a sparse perivascular lymphohistiocytic infiltrate. Keratohyalin granules were diffusely present within the parakeratotic stratum corneum, and the retained granular layer showed focal vacuolization. Granular parakeratosis is a rare form of parakeratosis most often seen in the axilla, although other intertriginous areas may be affected. Unique histopathologic findings allow for a specific diagnosis to be made. Although an irritant contact reaction appears causative, mechanical irritation may also play a role in inducing these skin changes.

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Citations

Sep 23, 2003·The American Journal of Dermatopathology·Kenneth S Resnik, Mario DiLeonardo
Jan 17, 2004·The American Journal of Dermatopathology·Kenneth S ResnikMario DiLeonardo
Sep 9, 2005·The American Journal of Dermatopathology·Kenneth S ResnikMario DiLeonardo
Feb 14, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Martin LaimerCesare Massone
Aug 20, 2014·Micron : the International Research and Review Journal for Microscopy·Kinga Skieresz-SzewczykMarlena Ratajczak
Jun 14, 2008·Journal of the American Academy of Dermatology·Laure JaconelliAlain Claudy
Mar 24, 2005·Skinmed·Larisa Ravitskiy, Warren R Heymann
Jan 12, 2008·The Australasian Journal of Dermatology·Carol Burford
Jul 31, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·J GenebrieraT A Borrowman
Dec 5, 2008·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Markus Braun-Falco, Helmut Laaff
Aug 22, 2013·International Journal of Dermatology·Gianluca NazzaroGianotti Raffaele
Nov 12, 2013·The British Journal of Dermatology·M W D Brouwer, P M J H Kemperman
Aug 6, 2015·American Journal of Clinical Dermatology·Catherine Y DingAmor Khachemoune
Apr 29, 2005·Journal of the American Academy of Dermatology·Noah S Scheinfeld, Joan Mones
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Oct 8, 2016·Journal of Cutaneous Pathology·José Carlos CardosoCatherine M Stefanato
May 3, 2019·The Australasian Journal of Dermatology·Sujith Prasad Wanniarachchi KumarasingheBenjamin Wood
Oct 1, 2019·The American Journal of Dermatopathology·Mizue FujiiAkemi Ishida-Yamamoto
May 16, 2019·BMJ Case Reports·Amy J ZhangA Mary Guo
Dec 24, 2018·The Journal of Dermatology·Toshio DemitsuMasaaki Kawase
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Mar 14, 2020·Indian Journal of Dermatology, Venereology and Leprology·Hage Jana Al-Ossama Abbas

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