PMID: 8470340Mar 1, 1993Paper

Granulated round cell tumor of cats

Veterinary Pathology
M F McEnteeD J Meuten

Abstract

Morphologic and biologic features of five feline granulated round cell tumours were compared with those previously reported to be of globule leukocyte and large granular lymphocyte origin. The five cats ranged from 6 to 9 years of age and presented with nonspecific gastrointestinal signs. Four of the five cats were tested for feline leukemia virus and were negative by enzyme-linked immunosorbent assay. The neoplastic process involved the abdominal cavity in all cases, with a predilection for the distal small intestine and mesentery. The liver and peripheral and thoracic lymphoid tissues were also sporadically affected. Neoplastic round cells contained 0.5-1.5-microns eosinophilic cytoplasmic granules that were difficult to discern on causal observation with hematoxylin and eosin stain but were deep blue and easily visualized when stained with phosphotungstic acid-hematoxylin. In two cases, epithelium in the affected ileum and liver contained unusually large numbers of apparently normal globule leukocytes. Ultrastructurally, the tumor granules tended to cluster at one nuclear pole and were spindle to round in shape with variably dense contents. Some granules contained a dense "cap" at one end or internal crystalloid bars that di...Continue Reading

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Citations

May 23, 1998·Comparative Immunology, Microbiology and Infectious Diseases·Y EndoA Hasegawa
Dec 1, 1994·Zentralblatt für Veterinärmedizin. Reihe A·S Saari, A K Järvinen
Jan 1, 1993·Veterinary Clinical Pathology·John KramerGerald Sloeojan
Jan 1, 1995·Veterinary Clinical Pathology·Laura I. BoonMark Drew
Jun 3, 2011·Veterinary Clinical Pathology·Melanie S SpoorLinda M Berent
Jan 1, 1995·Veterinary Clinical Pathology·Victoria L. ClydeRobert Donnell
Mar 25, 2015·Veterinary Parasitology·Miguel FuertesM Carmen Ferreras
Mar 31, 2001·Veterinary Pathology·P HerraezF Ramiro-Ibañez
Sep 13, 2006·Veterinary Pathology·M T MandaraM Sforna
Oct 1, 1998·Veterinary Pathology·J DarbèsW Hermanns
May 18, 2001·Veterinary Pathology·M NagataniK Tamura
Apr 20, 1999·Toxicologic Pathology·R MiyajimaM Enomoto
Aug 14, 2019·Journal of Toxicologic Pathology·Junko SatoMinoru Tsuchitani

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