PMID: 9645957Jul 1, 1998Paper

Granule cell development in the cerebellum is punctuated by changes in Sox gene expression

Brain Research. Molecular Brain Research
M RexP J Scotting

Abstract

Development of the vertebrate cerebellum is unusual compared to most other regions of the brain since it involves two germinal regions. Most cell types arise from the luminal, ventricular zone as in other brain regions, but granule cells arise from the second germinal layer, the external granular layer (EGL). Our analysis of the temporal and positional expression of three members of the Sox gene family of transcription factors in the cerebellum shows that granule cell development is unusual compared to most other neurons of the central nervous system (CNS). We show that granule cell precursors lose expression of cSox2 and cSox3 as they migrate to form the EGL. The EGL is the first example of a germinal layer in the CNS which does not exhibit expression of these genes. Throughout most of the CNS cSox11 expression is very low in the ventricular zone but increases dramatically as cells cease proliferation and migrate to form the subventricular zone. We also find that cSox11 expression increases when cells of the cerebellum migrate to form the EGL, but levels of expression as high as that in the subventricular zone are only seen when cells cease proliferation and migrate inwards to form the deep EGL. These observations demonstrate ...Continue Reading

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Citations

Jul 9, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C M LiS Z Wang
Aug 5, 2000·Brain Research. Molecular Brain Research·M CheungP J Scotting
Aug 18, 2012·Cellular and Molecular Life Sciences : CMLS·Giorgia Quadrato, Simone Di Giovanni
Mar 30, 2010·Journal of Cancer Research and Clinical Oncology·Feng YeHuaizeng Chen
Jun 16, 2011·Developmental Neurobiology·Darcie L Moore, Jeffrey L Goldberg
Mar 29, 2016·Autoimmunity Reviews·Guglielmo Lucchese, Darja Kanduc
Dec 18, 2013·Placenta·J SabenK Shankar
Sep 7, 2001·Developmental Biology·M Abu-ElmagdP J Scotting
Jan 15, 2005·Biochemical and Biophysical Research Communications·Woong SunHyun Kim
Oct 17, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Vasiliki Kommata, Catherine R Dermon
May 11, 2018·Histochemistry and Cell Biology·Karl Schilling

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