Granule cell raphes in the cerebellar cortex of chicken and mouse

Brain Research Bulletin
Christoph RediesK Arndt

Abstract

The cerebellar cortex of the chicken embryo contains parasagittal segments of Purkinje cells. At intermediate stages of development, cell-dense ribbons of migrating granule cells ("raphes") are found between the segments. The complementary pattern of granule cell raphes and Purkinje cell segments represents a basic scheme of cerebellar organization that coincides with the expression domains of various genes, such as cadherins, gene regulatory proteins, and ephrins and their receptors. We have recently found the raphe/segment pattern also in a mammalian species, the postnatal mouse. Like in the chicken, the parasagittal raphes of granule cells were observed at the boundaries of Purkinje cell segments that differentially express cadherins. The number and arrangement of the raphes in the different cerebellar lobules is roughly similar in both species. The raphe/segment pattern is thus more widely distributed in vertebrates than previously assumed.

References

May 1, 1968·Brain Research·H K Korneliussen
Feb 1, 1995·Neurology·J Piven, S Arndt
May 30, 1998·Molecular and Cellular Neurosciences·K ArndtC Redies
Feb 8, 2000·The International Journal of Biochemistry & Cell Biology·M Nakamoto
Apr 9, 2001·Cell and Tissue Research·R LucknerC Redies

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Citations

Oct 23, 2010·The Cerebellum·Jan Voogd
Jan 7, 2004·Journal of Physiology, Paris·Christoph RediesJiankai Luo
Oct 17, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Vasiliki Kommata, Catherine R Dermon

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