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Granulins modulate liquid-liquid phase separation and aggregation of TDP-43 C-terminal domain

bioRxiv

Oct 20, 2019

Anukool A BhopatkarVijayaraghavan Rangachari

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Abstract

Tar DNA binding protein (TDP-43) has emerged as a key player in many neurodegenerative pathologies including frontotemporal lobar degeneration (FTLD) and amyotropic lateral sclerosis (ALS). Important hallmarks of FTLD and ALS are the toxic cytoplasmic inclusions of C-terminal fragments ...read more

Mentioned in this Paper

Cell Nucleus
Cytoplasm
DNA-Binding Proteins
Pathology
RNA
Lateral Sclerosis
Caenorhabditis elegans
Athletes
3'-N-acetylfusarochromanone
Protein TDP-43
13
4
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Granulins modulate liquid-liquid phase separation and aggregation of TDP-43 C-terminal domain

bioRxiv

Oct 20, 2019

Anukool A BhopatkarVijayaraghavan Rangachari

DOI: 10.1101/812115

Abstract

Tar DNA binding protein (TDP-43) has emerged as a key player in many neurodegenerative pathologies including frontotemporal lobar degeneration (FTLD) and amyotropic lateral sclerosis (ALS). Important hallmarks of FTLD and ALS are the toxic cytoplasmic inclusions of C-terminal fragments ...read more

Mentioned in this Paper

Cell Nucleus
Cytoplasm
DNA-Binding Proteins
Pathology
RNA
13
4

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