Granulocyte activation during haemodialysis in the absence of complement activation: inhibition by calcium channel blockers

European Journal of Clinical Investigation
M Haag-WeberW H Hörl

Abstract

The effect of the calcium channel blockers nifedipine (9 and 18 micrograms kg-1 h-1), diltiazem (100 and 200 micrograms kg-1 h-1) and verapamil (19 micrograms kg-1 h-1) continuously infused during haemodialysis on granulocyte and complement activation was investigated. Plasma levels of lactoferrin, elastase in complex with alpha 1-proteinase inhibitor (E-alpha 1PI) and C3a were measured in patients dialysed with dialysers made of cuprophane, polymethylmethacrylate (PMMA) and polyacrylonitrile (PAN). Calcium channel blockers caused no change of blood pressure during haemodialysis in all patients. There was no effect of nifedipine, diltiazem or verapamil on plasma lactoferrin, E-alpha 1PI or C3a levels in patients dialysed with cuprophane. However, plasma lactoferrin and E-alpha 1PI values were significantly reduced by all calcium channel blockers in patients dialysed with PMMA, and also by nifedipine and verapamil in patients dialysed with PAN. Our data indicate that calcium channel blockers inhibit granulocyte activation occurring in dialysers with very little anaphylatoxin formation. These drugs, however, are ineffective in patients dialysed with cuprophane where complement activation takes place. Therefore, granulocyte activa...Continue Reading

References

Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D E Chenoweth, T E Hugli
Apr 7, 1977·The New England Journal of Medicine·P R CraddockH S Jacob
Jan 1, 1985·American Journal of Nephrology·W H HörlA Heidland
Jan 1, 1987·Contributions to Nephrology·G SchultzeM Molzahn
Jan 1, 1987·American Journal of Nephrology·R M SchaeferW H Hörl
Jul 15, 1987·Klinische Wochenschrift·W RiegelW H Hörl
Feb 21, 1985·The New England Journal of Medicine·M A ArnaoutH R Colten
Jan 1, 1983·Pharmacology & Therapeutics·W G Nayler, J D Horowitz
Aug 1, 1984·Kidney International·R M HakimJ M Lazarus
Jul 1, 1983·American Journal of Nephrology·W H HörlH Fritz
Jan 1, 1984·Advances in Experimental Medicine and Biology·S NeumannH Lang
Dec 1, 1983·Kidney International·P IvanovichD E Hammerschmidt
Dec 1, 1983·Kidney International·D E ChenowethL W Henderson
Oct 1, 1980·Kidney International·A I JacobJ J Bourgoignie
Nov 1, 1980·European Journal of Clinical Pharmacology·J GerrisA De Schaepdryver

Citations

Jan 1, 1993·Heart and Vessels·K HashimotoH Kurosawa
Nov 30, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S Schmaldienst, W H Hörl
Apr 1, 1989·Artificial Organs·M Haag-WeberW H Hörl
Feb 1, 1992·Journal of Autoimmunity·E MixH Link
Oct 13, 2017·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Piotr Jan NowakMichal Nowicki
Jan 1, 1991·Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology·H Schiffl, T Strasser
Jan 18, 2006·Journal of Pharmacological Sciences·Yoshiko KawaiMunekazu Gemba
Nov 1, 1994·Clinical and Experimental Immunology·A R RosenkranzG J Zlabinger

Related Concepts

Prolastin
Serum Proteins
Calcium Channel Blockers
Complement Activation
Granulocyte
Hemodialysis
Renal Dialysis Machine
Lactoferrin
Leukopenia
Elastase I

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