Granulocyte colony-stimulating factor- and chemotherapy-induced large-vessel vasculitis: six patient cases and a systematic literature review

Rheumatology Advances in Practice
Kirsi TaimenLaura Pirilä

Abstract

Patients receiving chemotherapy are prone to neutropoenic infections, presenting with non-specific symptoms such as a high fever and elevated inflammatory parameters. Large-vessel vasculitis (LVV) may have a similar clinical presentation and should be included in differential diagnostics. A few published case reports and adverse event reports suggest a causal association between LVV and the use of granulocyte colony-stimulating factor (G-CSF) and chemotherapy. Our objective was to evaluate the relationship between LVV, G-CSF and chemotherapy. Between 2016 and 2018, we identified six patients in Finland with probable drug-induced LVV associated with G-CSF and chemotherapy. All six patients had breast cancer. A systematic literature review was performed according to PRISMA guidelines using comprehensive search terms for cancer, chemotherapy, G-CSF and LVV. The literature search identified 18 similar published case reports, of which most were published after 2014. In all patients combined (n = 24), the time delay from the last drug administration to the LVV symptoms was on average 5 days with G-CSF (range = 1-8 days) and 9 days with chemotherapy (range = 1-21 days). Common symptoms were fever (88%), neck pain (50%) and chest pain ...Continue Reading

References

Apr 10, 1999·Molecular Biology of the Cell·A M YvonM A Jordan
Mar 3, 2004·La Revue de médecine interne·C DarieA Grand
Feb 25, 2005·AJR. American Journal of Roentgenology·Nadine BendixGerd Bodner
Nov 6, 2009·Clinical Drug Investigation·Giridhar U AdigaStefan Madajewicz
Jan 22, 2010·Rheumatology International·Lama Azar, Harry D Fischer
Apr 22, 2010·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Laura B RamsayChad A Hamilton
Sep 3, 2010·Mayo Clinic Proceedings·Lorraine C Pelosof, David E Gerber
Oct 26, 2011·Annals of Vascular Surgery·Marcus StanbroDwight C Kellicut
Jan 10, 2012·Leukemia & Lymphoma·Shaun FlemingJohn F Seymour
Apr 28, 2012·Blood·Stephanie M Wood, Yenan T Bryceson
Oct 10, 2012·Arthritis and Rheumatism·J C JennetteR A Watts
Sep 21, 2013·Annual Review of Pathology·Tanya N MayadasClifford A Lowell
Mar 4, 2014·International Journal of Hematology·Toby A EyreGraham P Collins
Jul 6, 2014·The New England Journal of Medicine·Cornelia M Weyand, Jörg J Goronzy
Oct 3, 2014·Singapore Medical Journal·Shinichi HayashiShu Hashimoto
Jul 15, 2015·Journal des maladies vasculaires·T BeharJ-P Galanaud
Oct 30, 2016·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Heidi HausmannApar K Ganti
Feb 3, 2016·Internal Medicine·Hiroko TsunemineTakayuki Takahashi
Mar 24, 2017·Vascular and Endovascular Surgery·Aleksandra PolichaNeal S Cayne
May 13, 2017·AJNR. American Journal of Neuroradiology·A LeclerJ C Sadik
May 27, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yuki SatoKeisuke Tomii
Jun 27, 2017·Scandinavian Journal of Rheumatology·S FukuiA Kawakami
Jul 18, 2018·American Journal of Hematology·Allison LardieriDaniel Woronow
Sep 2, 2018·Nature Reviews. Rheumatology·Leonard H CalabreseLaura C Cappelli
Nov 15, 2018·Seminars in Arthritis and Rheumatism·Francesco MuratoreCarlo Salvarani
Nov 25, 2018·Clinical Neuroradiology·Sila UlusErcan Karaarslan
Apr 9, 2019·Autoimmunity Reviews·Ioannis ParodisOscar P B Wiklander
Oct 28, 2019·Annals of the Rheumatic Diseases·Despina MichailidouPeter C Grayson

❮ Previous
Next ❯

Citations

May 27, 2020·VASA. Zeitschrift für Gefässkrankheiten·Juan José Soto CastilloJosé Miguel Blanc-Molina
Dec 11, 2020·Modern Rheumatology Case Reports·Koichiro YamamotoFumio Otsuka
Nov 14, 2020·Current Opinion in Rheumatology·Mustafa Erdogan

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
imaging techniques

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.