Granulocyte Colony-Stimulating Factor Attenuates Renal Ischemia-Reperfusion Injury by Inducing Myeloid-Derived Suppressor Cells.

Journal of the American Society of Nephrology : JASN
Ji-Jing YanJaeseok Yang

Abstract

Granulocyte colony-stimulating factor (G-CSF) can increase populations of myeloid-derived suppressor cells, innate immune suppressors that play an immunoregulatory role in antitumor immunity. However, the roles of myeloid-derived suppressor cells and G-CSF in renal ischemia-reperfusion injury remain unclear. We used mouse models of ischemia-reperfusion injury to investigate whether G-CSF can attenuate renal injury by increasing infiltration of myeloid-derived suppressor cells into kidney tissue. G-CSF treatment before ischemia-reperfusion injury subsequently attenuated acute renal dysfunction, tissue injury, and tubular apoptosis. Additionally, G-CSF treatment suppressed renal infiltration of macrophages and T cells as well as renal levels of IL-6, MCP-1, IL-12, TNF-α, and IFN-γ, but it increased levels of IL-10, arginase-1, and reactive oxygen species. Moreover, administering G-CSF after ischemia-reperfusion injury improved the recovery of renal function and attenuated renal fibrosis on day 28. G-CSF treatment increased renal infiltration of myeloid-derived suppressor cells (F4/80-CD11b+Gr-1int), especially the granulocytic myeloid-derived suppressor cell population (CD11b+Ly6GintLy6Clow); splenic F4/80-CD11b+Gr-1+ cells sorte...Continue Reading

References

Feb 4, 2005·Journal of the American Society of Nephrology : JASN·Masayoshi IwasakiSusumu Ikehara
Jan 18, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sang-Kyung JoHyoung-Kyu Kim
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Jun 6, 2009·Journal of the American Society of Nephrology : JASN·Gilbert R KinseyMark D Okusa
Jul 25, 2009·Kidney International·Maria Teresa GandolfoHamid Rabb
Feb 4, 2011·Journal of the American Society of Nephrology : JASN·Sik LeeLloyd G Cantley
Aug 2, 2011·Current Opinion in Immunology·Jason R LeesJonathan S Bromberg
Sep 29, 2011·Journal of Leukocyte Biology·Je-In YounDmitry I Gabrilovich
Apr 27, 2012·Immunologic Research·Jordi C Ochando, Shu Hsia Chen
Aug 18, 2012·Blood·Michael J Hickey
Oct 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Huanfa YiXiang-Yang Wang
Nov 13, 2012·The Journal of Clinical Investigation·Ming-Zhi ZhangRaymond C Harris
Jul 9, 2013·Journal of the American Society of Nephrology : JASN·Myung-Gyu KimJaeseok Yang
Oct 22, 2014·Nature Reviews. Nephrology·Hye Ryoun Jang, Hamid Rabb
Nov 13, 2014·Journal of the American Society of Nephrology : JASN·Sarah C HuenLloyd G Cantley
Jan 9, 2015·Journal of the American Society of Nephrology : JASN·Limin LiKe Zen
Apr 8, 2016·American Journal of Physiology. Renal Physiology·Melissa A PeguesAlexander J Szalai
May 27, 2016·Annals of the Rheumatic Diseases·Yan-Fang XingXing Li
Sep 13, 2016·Vaccines·Serena Zilio, Paolo Serafini
Dec 1, 2017·Transplantation·Joseph R ScaleaJonathan S Bromberg
Dec 20, 2017·Seminars in Immunology·Jie ZhouDmitry Gabrilovich
Mar 16, 2018·Current Opinion in Immunology·Suzanne Ostrand-Rosenberg
Aug 4, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Seiji MabuchiTadashi Kimura
Dec 18, 2018·Frontiers in Immunology·Snehil BudhwarKiran Singh
Dec 24, 2018·Journal of the American Society of Nephrology : JASN·Zhiyong WangSteven C Borkan

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Citations

Mar 10, 2020·Journal of the American Society of Nephrology : JASN·Alan D Salama, Mark A Little
Nov 19, 2020·International Journal of Molecular Sciences·André Renaldo FernándezMarcos López-Hoyos
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Haofeng ZhengQiquan Sun

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