PMID: 8970555Dec 1, 1996Paper

Granulocyte colony-stimulating factor enhances killing of translocated bacteria but does not affect barrier function in a burn mouse model

The Journal of Trauma
T Eaves-Pyles, J W Alexander

Abstract

Granulocyte colony-stimulating factor drives the proliferation and differentiation of granulocytes and also enhances their bactericidal and phagocytic activity. The present study was undertaken to investigate the effects of murine granulocyte colony-stimulating factor (mG-CSF) on bacterial translocation and gut-derived sepsis after burn injury. In experiment I, BALB/c mice were randomized into two treatment groups, which received 1 microgram/mouse of mG-CSF subcutaneously for either 1 (n = 16) or 2 days (n = 15). Controls received saline (n = 16). After treatment, all animals were gavaged with 10(10) 111In Escherichia coli and then given a 20% burn. All groups were observed 10 days for survival. In experiment II, three additional groups (n = 6/group) received the same treatment as above but were killed 4 hours after burn injury. Mesenteric lymph nodes, liver, and spleen were harvested to measure radionuclide counts (disintegrations per minute per gram of tissue) and colony-forming units (CFU/g of tissue) and to calculate the percentage of viable bacteria (% alive). Experiment I: 10-day survival was significantly higher in groups treated with mG-CSF for 1 or 2 days (75% and 73%, respectively), compared with controls (43.7%), p =...Continue Reading

References

Mar 1, 1991·The Journal of Clinical Investigation·F BussolinoA Mantovani
Nov 23, 1989·The New England Journal of Medicine·J E GroopmanD T Scadden
Nov 1, 1988·Archives of Surgery·T R ZieglerD W Wilmore
Nov 1, 1994·Journal of Applied Physiology·P Q EichackerT J MacVittie
May 1, 1993·The Journal of Burn Care & Rehabilitation·L GianottiG F Babcock

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