PMID: 11926293Apr 3, 2002Paper

Granulocyte colony-stimulating factor exacerbates the acute lung injury and pulmonary fibrosis induced by intratracheal administration of bleomycin in rats

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Kenji AdachKunio Doi

Abstract

We investigated the effects of granulocyte colony-stimulating factor (G-CSF) on lung injury induced by intratracheal administration of bleomycin (BLM, 2 mg/200 micro1) in rats. In experiment 1, G-CSF (10, 30 and 100 microg/kg/day, s.c.) was administered to rats treated with BLM or saline for 7 days starting immediately after BLM administration. In rats receiving G-CSF alone, a large number of neutrophils were noted in the pulmonary capillaries, although there were no lung lesions. In rats receiving BLM alone, diffuse alveolar damage was observed. The administration of G-CSF to BLM-treated rats increased the total lung lesion per unit of pulmonary parenchyma (total lung lesion %) along with increases in the peripheral neutrophil count and the number of neutrophils infiltrating in the pulmonary lesion in a dose-dependent fashion. In experiment 2, 100 microg/kg/day of G-CSF was administered to rats treated with BLM or saline for up to 28 days starting immediately after BLM administration. The administration of 100 microg/kg/day of G-CSF to BLM-treated rats showed no effects at 14 days but it increased the lung lesion % and the score of lung fibrosis along with the increase in the number of neutrophils infiltrating in the pulmonary...Continue Reading

Citations

Jul 7, 2009·Annual Review of Physiology·Qutayba Hamid, Meri Tulic
Dec 22, 2007·American Journal of Respiratory Cell and Molecular Biology·Fumitake SaitoAkitoshi Ishizaka
Aug 2, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yoshinori ItohRyozo Oishi
May 3, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Maria GaluppoSalvatore Cuzzocrea
Dec 30, 2009·Leukemia & Lymphoma·C VulstekeP Schöffski
Aug 6, 2008·Nature Clinical Practice. Oncology·Andrew M EvensVolker Diehl
Nov 20, 2012·Lung·Jai Prakash MuyalHarsh Bhardwaj

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