Granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) in Behçet's disease

The Journal of Dermatology
H TakahamaM Mizoguchi

Abstract

Increases in the number and activity of peripheral polymorphonuclear neutrophils (PMNs) is often found in Behçet's disease (BD), indicating that PMN may play an important role in the pathogenesis of this disorder. It has recently been reported that G-CSF and GM-CSF, a family of hematopoietic growth factors, enhance PMN activity. To explore the role of these two CSFs in BD, we first examined the chemotactic response of PMNs to these CSFs by performing a polarization assay. PMN response to G-CSF in BD patients was lower than that in controls, while PMN response to GM-CSF was similar in patients and controls. However, PMNs from BD patients showed an enhanced chemotactic response to N-formyl-L-methionyl-leucyl-phenylalanine. Thus, it is speculated that the PMNs of the patients might have already been activated in vivo by G-CSF and thus could not respond further to this agent in vitro. We examined G-CSF and GM-CSF mRNA expressions in peripheral mononuclear cells stimulated with LPS, PMA, and Con A by Northern hybridization. G-CSF mRNA expression levels in BD patients were higher than in the controls, while GM-CSF mRNA expression levels were lower than in the controls. We also examined the serum levels of the two CSFs by ELISA and EI...Continue Reading

References

Oct 25, 1975·Lancet·N Matsumura, Y Mizushima
Feb 1, 1979·The Journal of Clinical Investigation·C W SmithC Hassett
Mar 31, 1989·Journal of Immunological Methods·H MotojimaM Fukushima
May 1, 1987·The British Journal of Dermatology·M MizoguchiK Masuda
Aug 1, 1985·Journal of Cellular Physiology·N A Nicola, D Metcalf

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Citations

Dec 14, 1999·Clinical and Experimental Immunology·J FreysdottirF Fortune
Jun 1, 1997·Ocular Immunology and Inflammation·D A GamacheJ M Yanni
Jan 1, 2016·The American Journal of Pathology·Gabrielle L GoldbergIan P Wicks

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