Abstract
The clinical application of recombinant human G-CSF in patients with acute myeloid leukemia (AML) has been controversial because it stimulates the in vitro proliferation of leukemic cells. In order to explore the possibility of predicting in vivo leukemic proliferation after G-CSF administration to AML patients by using in vitro assays, we investigated the leukemic blasts of 30 AML patients, including 14 patients who received G-CSF for severe infection associated with neutropenia following chemotherapy (G-CSF group) and 16 patients who did not (control group). Of the 14 patients in the G-CSF group, 9 showed an increase of leukemic blasts in the peripheral blood during G-CSF administration, while 11 of the 16 control patients developed leukemic resurgence. In the G-CSF group, the frequency of leukemic resurgence among patients whose blasts showed dose-dependent proliferation after addition of G-CSF to cultures was similar to that among patients whose blasts did not. In addition, there were no significant differences between the G-CSF and control groups in [3H]thymidine incorporation by leukemic cells and leukemic colony formation after the addition of G-CSF to cultures. The G-CSF receptor affinity of leukemic blasts was signific...Continue Reading
References
Jan 1, 1977·Journal of Immunological Methods·M W BurgettJ F Monthony
Mar 1, 1992·Blood Reviews·K A Foon, R P Gale
Jul 1, 1991·British Journal of Haematology·J M BennettC Sultan
Sep 27, 1990·The New England Journal of Medicine·R OhnoY Sakai
Jan 1, 1991·British Journal of Haematology·T MotojiH Mizoguchi
May 15, 1991·Analytical Biochemistry·M WatanabeM Kusaka
Sep 1, 1985·Annals of Internal Medicine·J M BennettC Sultan
Jun 2, 1988·The New England Journal of Medicine·J L GabriloveLawrence Souza
Jul 1, 1988·Japanese Journal of Cancer Research : Gann·K ToyamaF Takaku
Oct 14, 1989·Lancet·W P SheridanR M Fox
Dec 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K M TaylorL M Souza
May 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A ThompsonA Fefer
Oct 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G MorstynK Alton
Dec 1, 1987·British Journal of Cancer·M H BronchudT M Dexter
Mar 26, 1988·Lancet·G MorstynR Fox
Jul 1, 1987·British Journal of Cancer·N NaraY Onozawa
Aug 20, 1987·The New England Journal of Medicine·P J FialkowR Veith
Oct 1, 1985·Annals of Internal Medicine·J M BennettC Sultan
Jun 1, 1982·British Journal of Haematology·J M BennettC Sultan
Jun 1, 1993·Annals of Hematology·R ScherrerC Sillaber
Oct 1, 1993·Annals of Hematology·O G OttmannD Hoelzer
Citations
May 19, 1998·Leukemia Research·H KawadaT Hotta
Jul 25, 1998·Leukemia Research·T MurayamaT Matsui
Feb 14, 2002·British Journal of Haematology·Kensuke UsukiUNKNOWN Gran AML Study Group
Mar 13, 2001·Leukemia·M SmeetsT de Witte
Oct 28, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lei GaoXi Zhang