Feb 18, 2020

Granulocyte-Colony Stimulating Factor reduces cocaine-seeking and downregulates glutamatergic synaptic proteins in medial prefrontal cortex

bioRxiv
Rebecca S HoffordDrew D Kiraly

Abstract

Background: Psychostimulant use disorder is a major public health issue, and despite the scope of the problem there are currently no FDA approved treatments. There would be tremendous utility in development of a treatment that could help patients both achieve and maintain abstinence. Previous work from our group has identified granulocyte-colony stimulating factor (G-CSF) as a neuroactive cytokine that alters behavioral response to cocaine, increases synaptic dopamine release, and enhances cognitive flexibility. Here, we investigate the role of G-CSF in affecting extinction and reinstatement of cocaine-seeking and perform detailed characterization of its proteomic effects in multiple limbic substructures. Methods: Sprague-Dawley rats were injected with PBS or G-CSF during (1) extinction or (2) abstinence from cocaine self-administration, and drug seeking behavior was measured. Quantitative assessment of changes in the proteomic landscape in the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) were performed via data-independent acquisition (DIA) mass spectrometry analysis. Results: Administration of G-CSF during extinction accelerated the rate of extinction, and administration during abstinence attenuated cue-induced...Continue Reading

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Mentioned in this Paper

Prune Belly Syndrome
Rats, Sprague-Dawley
Landscapes
Glutamate Receptor Signaling Pathway
Protein Expression
Dopamine
Synapses
Translational Research
Discovery Science
Study

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