Abstract
Neutropenia occurs in up to 17% of human immunodeficiency virus (HIV)-infected individuals. Although granulocyte colony-stimulating factor (G-CSF) can reverse HIV-related neutropenia, it is not established that this therapy can reduce bacterial infections and affect survival. A retrospective cohort study of 152 neutropenic, HIV-infected patients was performed to determine the therapeutic utility of G-CSF. Medical records of 71 patients who received G-CSF and 81 patients who never received G-CSF, during the years of 1991 to 1994 at Parkland Memorial Hospital, were reviewed for the incidence of bacteremia, G-CSF use, antiretroviral therapy (AR), Pneumocystis carinii pneumonia prophylaxis (PCPP), and opportunistic infections (OI). The two patient groups had similar baseline characteristics including CD4 count (37 cells/mm3 versus 40 cells/ mm3, P=0.7). Univariate analysis revealed and trend toward decreased rates of all bacteremias in the G-CSF-treated group compared with the controls (0.54 bacteremias/100 patient months versus 2.2 bacteremias/100 patient months, P=0.064) and a marked decrease in the rates of gram-negative rod bacteremias in the G-CSF-treated group compared with the untreated group (0.09 gram-negative rod bacterem...Continue Reading
References
Jun 1, 1992·Immunological Reviews·A SherH C Morse
Mar 1, 1991·The Journal of Infectious Diseases·E RoilidesM Rubin
Dec 1, 1990·AIDS·S KimuraF Takaku
Jul 18, 1991·The New England Journal of Medicine·J CrawfordG Rausch
Jul 1, 1991·British Journal of Haematology·P A van der WouwS A Danner
Sep 1, 1990·Lancet·C F GilksP G Waiyaki
Jun 1, 1989·The American Journal of Medicine·H M KrumholzB Lo
Dec 1, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M HeinkeleinC Jassoy
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V Trillet-LenoirD Tomita
Jan 1, 1995·International Journal of STD & AIDS·R A TorresD J Britton
Oct 1, 1994·Research in Immunology·M Clerici, G M Shearer
Jun 1, 1995·The Journal of Infectious Diseases·M M SchneiderJ C Borleffs
Mar 16, 1995·The New England Journal of Medicine·S A BozzetteJ Feinberg
Mar 16, 1995·The New England Journal of Medicine·W G PowderlyH Waskin
Nov 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W G Powderly
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S MakonkawkeyoonG Kaplan
Aug 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J E KaplanH W Jaffe
Aug 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J E KaplanW G Powderly
Dec 23, 1995·Lancet·E F BowenV C Emery
Dec 1, 1995·Antimicrobial Agents and Chemotherapy·P K PetersonC C Chao
Dec 1, 1995·AIDS·R D Moore, R E Chaisson
Feb 1, 1996·Medical Care·L A FriedmanB J Turner
Aug 8, 1996·The New England Journal of Medicine·M PierceJ C Craft
Aug 8, 1996·The New England Journal of Medicine·D V HavlirJ A McCutchan
Citations
Jun 26, 2001·Clinical and Experimental Immunology·A S Gonçalves, R Appelberg
Jul 9, 2014·Patient Safety in Surgery·Mareen BrumannWolf Mutschler
Dec 13, 2005·Sexual Health·Anthony JaworowskiSteven L Wesselingh
Sep 11, 2004·Journal of Clinical Epidemiology·Carl van WalravenGeorge A Wells
Nov 30, 2000·Current Infectious Disease Reports·D V Alcid, P Mathew
Dec 20, 1999·Journal of Hematotherapy & Stem Cell Research·W Welch, M Foote
Dec 20, 1999·Journal of Hematotherapy & Stem Cell Research·P HermansN Clumeck
May 26, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Rajko Reljic
Nov 28, 2002·Biological Chemistry·Lars Hareng, Thomas Hartung
Jun 17, 1999·Alcoholism, Clinical and Experimental Research·D A StoltzG J Bagby
May 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I Sereti, H C Lane
Jun 19, 2012·The Medical Clinics of North America·Vivek KakNancy Misri Khardori
Mar 25, 2014·International Reviews of Immunology·Xin ShiPing Zhang
Jun 19, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·R MurriA Antinori
Nov 28, 2001·Hematology·A M LevineA Krishnan
Oct 18, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·A M LevineL Ratner
Apr 20, 2002·AIDS·Michael DavidsonUNKNOWN Studies of Ocular Complications of AIDS Research Group
Nov 1, 2003·Intensive Care Medicine·Elie Azoulay, Christophe Delclaux
Oct 6, 2017·Archives of Virology·Mahmoud Mohammad YaseenBarakat Mohammad Shabsoug
Jan 4, 2020·Mucosal Immunology·Refilwe P MolatlhegiLyle R McKinnon
May 31, 2001·Critical Care Medicine·R A Proctor
Oct 31, 2020·Microbial Cell Factories·Sakshi Aggarwal, Saroj Mishra