PMID: 7537526Mar 1, 1995Paper

Granulocyte colony-stimulating factor administration modulates the surface expression of effector cell molecules on human monocytes

British Journal of Haematology
A OhsakaJ Igari

Abstract

Granulocyte colony-stimulating factor (G-CSF) has been shown to stimulate human neutrophil functions, both in vitro and in vivo. We examined the effects of G-CSF administration on the surface expression of effector cell molecules on human neutrophils and monocytes. G-CSF (50 micrograms/m2/d) was administered subcutaneously to five healthy volunteers once a day for 7 d. Venous blood was obtained immediately before and after the completion of G-CSF administration and 1 week after the last G-CSF administration. The surface expression of complement receptors (CR), Fc receptors for IgG(FcR) and cellular adhesion molecules on human neutrophils and monocytes were determined by indirect immunofluorescence using flow cytometry and monoclonal antibodies. The expression of CR1, CR3, FcRI and FcRII on neutrophils increased significantly after G-CSF administration and then decreased after the last G-CSF administration. The expression of human leucocyte adhesion molecule-1 (LAM-1) on neutrophils reflected the above expression. On the other hand, the administration of G-CSF increased the expression of CR1, CR3, FcRI and FcRIII on monocytes. The expression of CR1, CR3 and FcRI on monocytes then decreased after the last G-CSF administration, wh...Continue Reading

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Citations

Sep 1, 1996·Immunology Today·H W Ziegler-Heitbrock
Oct 3, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S RutellaG Leone
Dec 6, 2008·Current Opinion in Hematology·Paolo Anderlini
Oct 1, 1995·British Journal of Haematology·G Carulli
Jul 6, 2014·Mediators of Inflammation·Adam R JajtnerJay R Hoffman
Mar 30, 2010·International Immunopharmacology·Xuqin ZhuYajun Xu
Oct 2, 2019·Frontiers in Immunology·Thomas P HoferLoems Ziegler-Heitbrock
Oct 7, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yukio SatoYasunori Sohara
Feb 23, 2007·American Journal of Hematology·Lewis GlasserHarold M Horwitz
May 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael RehliReinhard Andreesen
Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K SuzukiS Kitagawa

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