PMID: 9450793Feb 5, 1998Paper

Granulocyte colony-stimulating factor administration increases serum concentrations of soluble selectins

British Journal of Haematology
A OhsakaJ Igari

Abstract

In order to explore the possible role of granulocyte colony-stimulating factor (G-CSF) in the inflammatory process, we examined the serum concentrations of soluble selectins (sL-selectin, sE-selectin and sP-selectin) following in vivo administration of G-CSF to five healthy volunteers and 12 neutropenic patients with haematological malignancies. The serum concentrations of both sL-selectin and sE-selectin were slightly but significantly increased after G-CSF administration in the healthy volunteers. The serum concentrations of all three selectins were significantly increased after G-CSF administration in the neutropenic patients concomitant with an increase in their neutrophil counts. These findings suggest that G-CSF may participate in the leucocyte-endothelial cell interactions in vivo.

Citations

Nov 20, 2002·British Journal of Haematology·Ralf HeroldChristoph Bührer
Dec 6, 2008·Current Opinion in Hematology·Paolo Anderlini
Jan 18, 2013·Case Reports in Nephrology and Urology·Swati AroraBarbara Clark
Sep 24, 2004·The British Journal of Surgery·S-M Sheen-ChenW-J Chen
May 4, 2018·Stem Cell Research & Therapy·Tzu-Lin ChenDer-Shan Sun

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