PMID: 12753369May 20, 2003Paper

Granulocyte elastase activity in static and flow gingival crevicular fluid

Journal of Periodontal Research
Lijian JinE F Corbet

Abstract

This study aimed to evaluate the volume of gingival crevicular fluid (GCF) and granulocyte elastase activity in static GCF (sGCF) and flow GCF (fGCF) from subjects with various periodontal conditions. Eleven periodontally healthy, 10 gingivitis and 12 periodontitis subjects were recruited and the sites investigated consisted of healthy sites from healthy subjects (HH); healthy (HG) and gingivitis sites (GG) from gingivitis subjects; and healthy (HP), gingivitis (GP) and periodontitis sites (PP) from periodontitis subjects. fGCF samples were collected either 1 min or 5 min following sGCF collection by paper strip technique. GCF volume was determined by Periotron 6000 and granulocyte elastase activity was assayed with a specific substrate [l-pyroglutamyl-l-prolyl-l-valine-p-nitroanilide(pGluProVal-pNA)]. At baseline, no significant differences existed in clinical and GCF parameters between the two matched sites for subsequent collection of fGCF samples either 1 min or 5 min after sGCF sampling in all subjects. The flow exudate in HG and HP sites quickly replenished to sGCF levels, while a delayed replenishment was found in HH sites, despite the similar sGCF volumes of these sites. The GCF volume and elastase levels in the fGCF at...Continue Reading

References

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Citations

Apr 3, 2007·Journal of Periodontology·Hasan HatipoğluKenan Eratalay
Oct 23, 2013·Journal of Periodontology·Sevim GündayNermin Yamalik
Aug 18, 2009·Journal of Clinical Periodontology·Benedict StaabHolger Jentsch
Oct 23, 2008·Journal of Periodontal Research·T MatsuyamaY Izumi

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