PMID: 8601605Apr 1, 1996Paper

Granulocyte macrophage colony stimulating factor produced in lesioned peripheral nerves induces the up-regulation of cell surface expression of MAC-2 by macrophages and Schwann cells

The Journal of Cell Biology
A SaadaS Rotshenker

Abstract

Peripheral nerve injury is followed by Wallerian degeneration which is characterized by cellular and molecular events that turn the degenerating nerve into a tissue that supports nerve regeneration. One of these is the removal, by phagocytosis, of myelin that contains molecules which inhibit regeneration. We have recently documented that the scavenger macrophage and Schwann cells express the galactose-specific lectin MAC-2 which is significant to myelin phagocytosis. In the present study we provide evidence for a mechanism leading to the augmented expression of cell surface MAC-2. Nerve lesion causes noneuronal cells, primarily fibroblasts, to produce the cytokine granulocyte macrophage-colony stimulating factor (GM-CSF). In turn, GM-CSF induces Schwann cells and macrophages to up-regulate surface expression of MAC-2. The proposed mechanism is based on the following novel observations. GM-CSF mRNA was detected by PCR in in vitro and in vivo degenerating nerves, but not in intact nerves. The GM-CSF molecule was detected by ELISA in medium conditioned by in vitro and in vivo degenerating peripheral nerves as of the 4th h after injury. GM-CSF activity was demonstrated by two independent bioassays, and repressed by activity blockin...Continue Reading

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Citations

Dec 14, 2004·Journal of Neurology·Jorge Correale, Andrés Villa
Nov 1, 1996·Journal of Neuroimmunology·F Reichert, S Rotshenker
Sep 12, 2002·Biochimica Et Biophysica Acta·André DanguyRobert Kiss
Dec 1, 1996·Current Opinion in Cell Biology·T S Zorick, G Lemke
Dec 11, 2003·Molecular and Cellular Neurosciences·Susna DeSamuel David
Oct 10, 1998·The European Journal of Neuroscience·H Be'eriS Rotshenker
May 18, 2007·Annual Review of Neuroscience·Mauricio E Vargas, Ben A Barres
Sep 1, 2011·Journal of Neuroinflammation·Shlomo Rotshenker
Apr 18, 2014·Journal of Clinical Immunology·Nevena TzekovaPatrick Küry
Dec 2, 1999·Journal of Neuroimmunology·J L RutkowskiS L Kunkel
Sep 12, 2015·Expert Opinion on Therapeutic Targets·Xiujuan WuHong-Liang Zhang
Feb 24, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lei Wang, Xiu-Li Guo
Oct 26, 2012·Journal of Neuropathology and Experimental Neurology·Laurence RichardJean-Michel Vallat
Aug 25, 2009·Molecular Immunology·Caroline M W van StijnIrma van Die
Jul 29, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Ana Paula Fernandes BertocchiNiels Olsen Saraiva Câmara
Apr 4, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Chen-Jung ChangShih-Kuang Hsu
Feb 16, 2006·Biochimica Et Biophysica Acta·Jerka DumicMirna Flögel
Nov 18, 2005·Injury·Elizabeth O JohnsonPanayotis N Soucacos
Jan 5, 2000·Experimental Neurology·F Reichert, S Rotshenker
Sep 23, 2014·Neuroscience·A DeFrancesco-LisowitzR E Zigmond
Apr 5, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Petr Dubový
Nov 27, 2008·Journal of the Neurological Sciences·Xian HuangByung Hyune Choi
May 7, 2009·Experimental Neurology·Marcelo Sampaio NarcisoAna Maria Blanco Martinez
Sep 22, 2000·Current Review of Pain·M Tal
Dec 8, 2015·Clinical Medicine Insights. Oncology·Hafiz Ahmed, Dina M M AlSadek
Aug 14, 2018·The European Journal of Neuroscience·André Luis BombeiroAlexandre Leite Rodrigues de Oliveira

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