PMID: 46510Feb 15, 1975

Granulocyte transfusions in treatment of infections in patients with acute leukaemia and aplastic anaemia

Lancet
R M LowenthalD A Galton

Abstract

By use of the continuous-flow blood-cell separator 137 bags of granulocyte-rich plasma were obtained from normal donors (59 bags) and patients with chronic granulocytic leukaemia (C.G.L.) (78 bags). Eighty-nine courses of granulocyte transfusion therapy consisting of 1 or more such bags were administered to forty-one ABO-compatible patients with acute leukaemia or aplastic anaemia, who had definite or probable infections that had failed to respond to antibiotics. The fever resolved after 67% of courses of transfusions of two or more bags but after only 24% of transfusions of single bags of granulocytes (p less than 0-01), and this result suggests that this form of treatment is in general effective. Granulocytes from C.G.L. and normal donors were equally effective, although transfusion reactions were commoner after C.G.L. cells (33% versus 12%, respectively, p less than 0-05). C.G.L. grafts, and probable graft-versus-host disease, occurred in three recipients of unirradiated C.G.L. cells. Recipients of normal cells whose fevers resolved received on average four times as many granulocytes per sq.m. as those fevers did not respond. No such difference was found when C.G.L. cells were used. The fever was more likely to resolve in re...Continue Reading

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Related Concepts

Mycoses
Aplastic Anemia
Acute Leukemia
Peripheral Blood
Antibiotic throat preparations
Graft-vs-Host Disease
Antifungal Antibiotics, Topical
Opitz-G Syndrome, Type 2
Granulocyte Count
Acute Disease

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