Granulocytic sarcoma of mesentery in acute myeloid leukemia with CBFB/MYH11 fusion gene but not inv(16) chromosome: case report and review of literature

Leukemia Research
Atsushi FujiedaHiroshi Shiku

Abstract

Granulocytic sarcoma (GS) is a rare extra-medullary tumor and usually involves the skin, soft tissue, and lymph nodes. GS is found in 8% of acute myeloid leukemia (AML) patients, especially patients with t(8;21)AML. It has been suggested that GS is a poor prognostic factor in t(8;21)AML. Compared to t(8;21)AML, GS is rare in cases of inv(16)AML. Thus, the characteristics of inv(16) with GS are not well understood. Here, we describe a patient with AML and mesentery GS. The chromosomal analysis was normal, but molecular analysis detected the CBFB/MYH11 fusion gene in the blasts. A complete remission was achieved with standard induction therapy followed by high-dose cytarabine consolidation. We have also summarized 12 reported cases of inv(16)AML with GS and found that GS was commonly found in abdominal lesions. These observations suggest that when abdominal GS is diagnosed, an analysis of the CBFB/MYH11 fusion gene is necessary to make an appropriate decision regarding treatment options, even if no chromosomal abnormalities are found.

References

Aug 26, 2000·Genes, Chromosomes & Cancer·H Pirc-DanoewinataO A Haas
Mar 22, 2003·Blood·Jacques DelaunayUNKNOWN Bordeaux-Grenoble-Marseille-Toulouse cooperative groups
Aug 22, 2003·European Journal of Haematology·Guido MarcucciClara D Bloomfield
Mar 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John C ByrdClara D Bloomfield
Mar 26, 2004·Cancer Genetics and Cytogenetics·Ming LiJinlan Pan

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Citations

Jan 9, 2007·Annals of Hematology·Maximilian ChristopeitGerhard Behre
Feb 28, 2014·Journal of Oral and Maxillofacial Pathology : JOMFP·Başak KurdoğluBurcu Sengüven
Jan 27, 2016·Leukemia Research·Desheng XiaoYongguang Tao
Dec 5, 2012·Seminars in Oncology·Madhava BaikaidiGloria J Morris
Jul 18, 2015·American Journal of Clinical Pathology·Carla S Wilson, L Jeffrey Medeiros
Nov 6, 2007·Cancer Genetics and Cytogenetics·Mar MalloFrancesc Solé
Nov 27, 2007·Cancer Genetics and Cytogenetics·Gudrun GöhringBrigitte Schlegelberger
Jun 4, 2011·Hematological Oncology·Batia AvniOra Paltiel
Aug 15, 2018·American Journal of Hematology·Isabel Cunningham, Daniel Worthley
Jan 7, 2020·Current Opinion in Hematology·Omar A Shahin, Farhad Ravandi
Apr 9, 2013·Annals of Saudi Medicine·Ipek YonalSevgi Kalayoglu-Besisik
Nov 2, 2019·American Journal of Clinical Pathology·Joanna C DallandKaaren K Reichard

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