Granulocytic sarcoma of the pancreas: a case report and review of the literatures.

BMC Gastroenterology
Yefei RongDayong Jin

Abstract

Granulocytic sarcoma (GS) is a form of acute myeloid leukemia (AML), also known as extramedullary myeloid tumor or chloroma. It forms a solid malignant tumor consisting of myelocytes or granulocytes and is typically located in bone while occurrence in other parts of the body is rare. We reported a 40-year-old male patient who had jaundice, highly elevated bilirubin, and a mass highly suspicious of pancreatic head carcinoma. We performed surgery and the pathology and immunohistochemistry suggested GS; however the blood test and the bone marrow infiltration showed no evidence of AML. In our review of the published reports of GS, we only found six reports of the GS in the pancreas, and we suggested that immunohistochemical staining should be used to accurately differentiate GS from other pancreatic cancer and other types of leukemia. The accurate diagnosis of GS is necessary for determining prognosis and deciding appropriate therapy.

References

Oct 1, 1993·The American Journal of Surgical Pathology·S T TraweekR K Brynes
Apr 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M S TallmanD Variakojis
Sep 2, 1998·Medical and Pediatric Oncology·R SchwyzerP Willem
Dec 16, 2006·Leukemia & Lymphoma·Semra PaydasMelek Ergin
May 6, 2008·Leukemia Research·Henning Sebastian SchäferMichael Lübbert

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Citations

Dec 3, 2011·Annals of Hematology·Georgia D KaiafaVassiliki Kaloutsi
Feb 19, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Navid TabrizDirk Weyhe
Jan 29, 2011·World Journal of Gastroenterology : WJG·Xin-Ping LiYue-Zu Fan
Jun 6, 2012·Case Reports in Medicine·Laxmi ParsaDavid Stein
Jan 7, 2011·Case Reports in Medicine·Ibrahim ElghissassiHassan Errihani
Feb 18, 2012·American Journal of Clinical Pathology·Jonathan RockWendy L Frankel
Aug 15, 2014·Abdominal Imaging·Kumar SandrasegaranChristine O Menias
Dec 9, 2016·Medicine·Akira IshiiAkifumi Takaori-Kondo

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Methods Mentioned

BETA
surgical resection
biopsy

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