Granulocytic sarcoma of the spine in nonleukemic patients: report of three cases

Neurosurgery
S DemeJ M Bilbao

Abstract

Granulocytic sarcomas involving the spine in patients without myelogenous leukemia are rare. We report three cases and review the literature. Three patients presented with spinal epidural tumors, which caused spinal cord compression in one and cauda equina compression in two. All patients underwent surgery, and biopsies revealed histological features of granulocytic sarcomas. Bone marrow aspirates and biopsies showed no evidence of acute leukemia at initial presentation, for all three patients. Granulocytic sarcomas in nonleukemic patients are rare, and when they affect the spine they are frequently misdiagnosed. Appropriate therapy for these tumors requires early identification.

References

Jan 1, 1990·Magnetic Resonance Imaging·P Ang, C Virapongse
Sep 1, 1988·The American Journal of Surgical Pathology·F R DaveyD Y Mason
Dec 15, 1986·Cancer·J M MeisJ T Manning
Apr 1, 1984·Australian and New Zealand Journal of Medicine·S J Kellie, K D Waters
Oct 1, 1993·The American Journal of Surgical Pathology·S T TraweekR K Brynes
Feb 1, 1963·The American Journal of Medicine·D E WILHYDES MULLAN
Apr 1, 1950·Journal of Neuropathology and Experimental Neurology·A B RAGINS, M TINSLEY
Oct 1, 1945·Archives of Surgery·H A SHENKINF C GRANT

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Citations

Aug 4, 2009·Journal of Pediatric Hematology/oncology·Lale OlcayMustafa Gökçe
Jan 26, 2017·Journal of Pediatric Hematology/oncology·Yueli RaoJie Yan
Jul 17, 2001·Medical and Pediatric Oncology·E NijlandP van Diest
Mar 26, 2008·Neurologia Medico-chirurgica·Tomoo InoueTeiji Tominaga
Aug 19, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Rohit AmritanandGabriel D Sundararaj
Mar 30, 2000·Clinical Orthopaedics and Related Research·T O'BrienH DeGroot
May 30, 2001·Leukemia & Lymphoma·M TresoldiC Rugarli
Jul 14, 2005·European Journal of Pediatrics·Yusuke ShiozawaYuichiro Yamashiro
May 25, 2007·International Ophthalmology·Kamel HmidiMoncef Khairallah
Dec 12, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·S UgrasB Guven
May 22, 2021·Pediatric Hematology and Oncology·Sarah SalouChristian Flotho

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