PMID: 15218417Jun 26, 2004Paper

Granulocytic sarcoma presenting as pneumonia in a child with t(8;21) acute myelogenous leukemia: diagnosis by fluorescent in situ hybridization

Journal of Pediatric Hematology/oncology
Dean A LeeChing C Lau

Abstract

Granulocytic sarcoma is a soft tissue collection of leukemic cells. The authors describe a 4-year-old boy with M2 acute myelogenous leukemia (AML) who presented with fever, mild nonproductive cough, and hematemesis. Although he was initially diagnosed with nodular pneumonia, rapid resolution of a pulmonary infiltrate following induction chemotherapy was suggestive of a pulmonary granulocytic sarcoma. Interphase fluorescent in situ hybridization (FISH) of the lung biopsy specimen for the t(8;21)(q22;q22) translocation confirmed the retrospective diagnosis of a well-differentiated pulmonary granulocytic sarcoma. Pulmonary granulocytic sarcomas may be underrecognized in children with AML; this may delay anti-leukemic therapy and may lead to ineffective therapy if misdiagnosed as pneumonia.

References

Oct 25, 1986·Schweizerische medizinische Wochenschrift·B Speck
Jun 1, 1983·Cancer Genetics and Cytogenetics·Y KanekoT Fujimoto
Jan 1, 1996·Journal of Thoracic Imaging·J E TakasugiS H Petersdorf
May 1, 1997·Leukemia·M T Elghetany
Jun 6, 2000·Acta Haematologica·M BangerterM Griesshammer
Jan 27, 2004·The Journal of Pathology·Madhav Bhatia, Shabbir Moochhala

❮ Previous
Next ❯

Citations

Nov 6, 2007·Cancer Genetics and Cytogenetics·Mar MalloFrancesc Solé
Jun 2, 2011·Journal of Biomedicine & Biotechnology·Håkon ReikvamØystein Bruserud
Feb 14, 2009·Leukemia Research·Jew-Win KuanSen-Moi Tan
Apr 25, 2007·Pediatric Hematology and Oncology·Dragana JanicPredrag Rodic
Mar 19, 2014·Indian Pediatrics·Rajat ThawaniLata Jadhav
Jun 28, 2020·Seminars in Diagnostic Pathology·Joseph D Khoury, Weina Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Acute Myeloid Leukaemia & RNA

Acute myeloid leukaemia (AML) is a common hematological type of cancer. As the population ages, there has been a rise in the frequency of AML. RNA expression has been used to see if there are different genetic profiles that exist within AML and whether these may underpin the variations in survival rates. Here is the latest research on AML and RNA.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.