PMID: 8609810Dec 1, 1995Paper

Granulomas in primary sclerosing cholangitis

Liver
J LudwigJ J Poterucha

Abstract

Granulomas in liver biopsy specimens from adult patients with chronic ductopenic cholestatic liver disease are a characteristic feature of primary biliary cirrhosis. However, we found a similar combination of abnormalities in 7 out of 100 native livers (7%) from patients who had orthotopic liver transplantation for primary sclerosing cholangitis. In a control group of native livers from 100 patients with primary biliary cirrhosis, the prevalence of granulomas was exactly the same, 7%. In the primary sclerosing cholangitis group, 13 addition livers showed a granulomatous epithelioid cell response, with or without foreign body type giant cells, to extravasated bile. All granulomas were noncaseating and non-necrotizing; they consisted of epithelioid cells and often contained giant cells. Perigranulomatous lymphocytic infiltrates were generally mild to moderate. The granulomas involved portal tracts, scars, and hepatic parenchyma. Biopsy experience revealed that granulomas can be found in all stages of the disease. In contradistinction to the granulomas in primary biliary cirrhosis, the granulomas in primary sclerosing cholangitis did not represent granulomatous cholangitis--that is, they were not a feature of the duct destruction....Continue Reading

References

Oct 1, 1990·Journal of Clinical Gastroenterology·J R MurphyZ Goodman
Apr 5, 1984·The New England Journal of Medicine·N F LaRussoR L MacCarty
May 1, 1982·Gut·N M BassS Sherlock

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Citations

May 9, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mary K Washington
Nov 8, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·F A AnaniaC I Drachenberg
Mar 16, 2007·Seminars in Diagnostic Pathology·David E Kleiner

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