Granulomatous inflammation in juvenile idiopathic arthritis-associated uveitis

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Jeremy D KeenanDebra A Goldstein

Abstract

The uveitis that is associated with juvenile idiopathic arthritis (JIA) has typically been described as nongranulomatous. This study reports the prevalence of granulomatous disease in a population with JIA-associated uveitis. We conducted a retrospective analysis of all patients with JIA-associated uveitis seen between 1973 and 2006 at a hospital-based uveitis service. Patients with uveitis were included if they were diagnosed with JIA by a specialist and experienced at least 6 weeks of arthritis starting before the age of 16 years. Granulomatous disease was defined as Busacca or angle nodules, mutton-fat keratic precipitates (KP), or hyalinized "ghost" KPs. Statistical tests were performed to seek associations between granulomatous disease and various clinical factors. Seventy-one patients with JIA-associated uveitis were included. Granulomatous uveitis was observed in 28% of the population, with 7% exhibiting mutton-fat KP, and 21% "ghost" KP. There was no association between the presence of granulomatous disease and age of arthritis onset, age of uveitis onset, sex, antinuclear antibody status, or whether the arthritis was pauciarticular or polyarticular. In this population, 67% of black patients had granulomatous disease co...Continue Reading

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Citations

Apr 9, 2014·Drug Design, Development and Therapy·Francesco SemeraroCiro Costagliola
Jan 1, 2014·Oman Journal of Ophthalmology·Parthopratim Dutta Majumder, Jyotirmay Biswas
Jul 6, 2014·Ocular Immunology and Inflammation·Yung-Ray Hsu, Chang-Ping Lin
May 30, 2013·Ocular Immunology and Inflammation·Manfred ZierhutIlknur Tugal-Tutkun
Dec 23, 2008·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Emmett T Cunningham, Eric B Suhler
May 19, 2017·Zeitschrift für Rheumatologie·C Springer-Wanner, T Brauns
Oct 28, 2019·Immunological Medicine·Kazuichi Maruyama
Jul 9, 2011·Current Opinion in Rheumatology·C Egla Rabinovich
Dec 3, 2016·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·J G Garweg
Mar 18, 2021·Clinical Ophthalmology·Ioannis Papasavvas, Carl P Herbort
Jul 16, 2021·Frontiers in Pediatrics·Luca MarelliElisabetta Miserocchi

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