PMID: 18209299Jan 23, 2008Paper

Granulomatous Interstitial Nephritis and Acute Renal Failure due to Renal-limited Sarcoidosis

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
K A El-ReshaidJ P Madda

Abstract

Renal failure secondary to granulomatous sarcoidosis without clinical features or radiological evidence of disease is rare. In this case report, we describe a 14-year old girl who developed progressive renal failure over a two-month period which was associated with weight loss and epigastric pain. Physical examination did not show any abnormality. Laboratory investigations were normal except for normocytic normochromic anemia, high serum urea, high serum creatinine (452 tmol/L) and polyclonal gammopathy. Percutaneous kidney biopsy showed severe interstitial nephritis with non-caseating granulomata. She was treated with tapered prednisone after a starting dose of 1 mg/kg. The treatment with prednisolone resulted in a complete remission that lasted up to two years of follow up. This case highlights the variable expression of sarcoidosis, which should be considered in the management of such disease.

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Asha MoudgilKanwal K Kher
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Michelle N RheaultAlan R Sinaiko
International Urology and Nephrology
Abdulkadir UnsalMustafa Sevınc
European Journal of Internal Medicine
Nilgun ErtenCemil Tascioglu
© 2021 Meta ULC. All rights reserved