Granulomatous interstitial nephritis in a renal allograft

CEN Case Reports
Noriko NunotaTadao Akizawa

Abstract

We describe a middle-aged woman in whom granulomatous interstitial nephritis (GIN) developed in a renal allograft. She had undergone bowel resection due to an uncertain diagnosis of active granulomatous bowel disease 30 years earlier. Thereafter, frequent hyperoxaluria as well as calcium oxalate stone and recurrent urinary tract infections had resulted in a progressive deterioration in kidney function over a period of 20 years. She underwent living donor kidney transplantation; however, her kidney function progressively deteriorated, despite transplantation. A biopsy of the renal allograft revealed GIN with granulomatous vasculitis accompanied by calcium oxalate crystals. These as well as the laboratory findings indicated a diagnosis of sarcoidosis. We considered that the aggravated granulomatous inflammation on the allograft was caused by recurrent sarcoidosis accompanied by hyperoxaluria.

References

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Apr 25, 2008·Kidney International·Kathearine DahlJai Radhakrishnan
Dec 24, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Serena M BagnascoEdward Kraus
Feb 20, 2009·Kidney International·Bernd HoppeDawn S Milliner
Feb 20, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Katja B P ElgstoenAnders Hartmann
Jul 31, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Jessie AouizeratePhilippe Grimbert
Aug 1, 2010·NDT Plus·Jessica B LapasiaJane C Tan

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