Granulomatous-lymphocytic interstitial lung disease associated with common variable immunodeficiency: CT findings

Journal of Thoracic Imaging
Drew A TorigianWallace T Miller

Abstract

To evaluate computed tomography (CT) scans of individuals with granulomatous-lymphocytic interstitial lung disease and common variable immunodeficiency (CVID) to determine if there are imaging features that distinguish this manifestation of CVID from the more usual imaging findings. A review of the CVID population at our institution identified a series of 5 patients with CVID who had documented granulomatous disease on biopsy specimens. The initial and follow-up CT examinations were reviewed by 2 radiologists, and imaging findings in the chest and abdomen were tabulated by consensus. In addition, a pathologist reviewed histopathologic specimens and clinical presentations and therapeutic interventions were obtained from patient charts. In all, 5/5 patients (100%) had widespread pulmonary micronodules with a lower lung zone predominance, 4/5 (80%) had smooth interlobular septal thickening with mid to lower lung zone predominance, 1/5 (20%) had mild bronchiectasis, 4/5 (80%) had multifocal pulmonary consolidation, 5/5 (100%) had thoracic or abdominal lymphadenopathy, 2/5 (40%) had hepatomegaly, 5/5 (100%) had splenomegaly, 1/5 (20%) had nonspecific hypoattenuating splenic lesions, and 2/5 (40%) had nonspecific hypoattenuating rena...Continue Reading

References

May 1, 1993·Annals of Internal Medicine·M C SnellerC Cunningham-Rundles
Dec 1, 1996·The British Journal of Radiology·A FeydyJ Frija
Oct 27, 1997·Annals of Internal Medicine·L J MechanicC Cunningham-Rundles
Jul 22, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·C Cunningham-Rundles, C Bodian
Aug 2, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F FakhouriP F Plouin
Aug 2, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F FakhouriP Lesavre
Sep 27, 2002·QJM : Monthly Journal of the Association of Physicians·K M ThickettD E Stableforth
Jun 27, 2003·Drugs·W A Carrock SewellStephen R A Jolles
Dec 13, 2003·Archives of Disease in Childhood·F RusconiM C Pietrogrande
Feb 14, 2004·The Australasian Journal of Dermatology·Karyn R LunRowland Noakes
Aug 19, 2004·The Journal of Allergy and Clinical Immunology·Christopher A BatesJohn M Routes
May 19, 2005·European Journal of Radiology·J E S ParkJ Haddock
Aug 17, 2005·The Journal of Experimental Medicine·William H WheatJohn M Routes
May 19, 2007·Journal of Clinical Immunology·Isabella QuintiUNKNOWN Italian Primary Immunodeficiency Network

❮ Previous
Next ❯

Citations

Sep 19, 2012·Journal of Clinical Immunology·Jean-Nicolas BoursiquotUNKNOWN DEFI study group
Feb 10, 2016·Current Allergy and Asthma Reports·Paul J Maglione
Sep 12, 2012·Archivos de bronconeumología·Ana Camarasa EscrigJose Manuel León Ramírez
Mar 20, 2012·La Revue de médecine interne·M PavicP Sève
Jun 14, 2015·Revue des maladies respiratoires·J HadjadjA Bergeron
Aug 15, 2014·Frontiers in Pediatrics·Milos JesenakEva Babusikova
Mar 4, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Stella HartonoAvni Y Joshi
Sep 15, 2017·Respiration; International Review of Thoracic Diseases·Yurdagül UzunhanDominique Valeyre
Aug 2, 2018·Journal of Thoracic Imaging·Tami J BangDavid A Lynch
Jun 6, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Muhammad NaeemSanjeev Bhalla
Oct 27, 2018·BioMed Research International·Ran LiZhancheng Gao
Oct 17, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F M C A PimentaA S Grumach
Dec 12, 2019·The New England Journal of Medicine·Robert W HallowellLida P Hariri
Apr 12, 2016·Annals of the American Thoracic Society·Amar ManninaEvans R Fernández Pérez
May 8, 2018·Journal of Immunology Research·Giovany Gomes CapistranoAlexandre Braga Libório
Dec 18, 2020·Frontiers in Immunology·Fatima DhallaSmita Y Patel
Jul 14, 2020·Immunology and Allergy Clinics of North America·Paul J Maglione

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Joon H Park, Arnold I Levinson
The Journal of Allergy and Clinical Immunology
Christopher A BatesJohn M Routes
Allergologia et immunopathologia
Beatriz T Costa-CarvalhoDirceu Solé
© 2022 Meta ULC. All rights reserved