PMID: 1206417Nov 1, 1975Paper

Granulomatous myopathy: its relationship to sarcoidosis and polymyositis

Journal of Neurology, Neurosurgery, and Psychiatry
R H Hewlett, B Brownell

Abstract

In three cases of generalized muscle weakness, muscle biopsy revealed well-defined, non-caseating epithelioid granulomata with giant cells. In one of these patients there was, in addition, a high serum CPK and histological evidence of widespread muscle cell degeneration and regeneration, apparently unrelated to the granulomatous process. In a re-examination of the histopathology of these cases, using biopsy material from a fourth case of proven sarcoidosis as a standard, it was concluded that there are no special features of the granulomatous/giant cell process which permit the separation of the case of presumed polymyositis. However, it appeared that granulomata per se do not exert a significant ill effect on surrounding muscle cells, and that evidence of widespread degeneration of muscle cells is the important point of distinction.

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Citations

Oct 4, 2002·Muscle & Nerve·Christian BergerHans-M Meinck
Jun 1, 1980·Irish Journal of Medical Science·D SugrueM I Drury
May 12, 2007·Skeletal Radiology·S SureshP O'Donnell
Jun 15, 2007·Modern Rheumatology·Hideyasu YamadaTakayuki Sumida
Feb 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·Y HartR O McKeran
Nov 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·N J Simmonds, B I Hoffbrand
Sep 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·D S Tews, D E Pongratz
Jul 1, 1985·Pathology, Research and Practice·H H GoebelW Dippold
Nov 1, 2009·Reumatología clinica·Arnulfo Nava, Gerardo Orozco-Barocio
Sep 9, 2015·Multiple Sclerosis and Related Disorders·Heather J MacLean, Mohammad Abdoli
Oct 28, 2006·Muscle & Nerve·Karine Le RouxPascal Sève
Jul 22, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·S CollinsE Byrne
Oct 1, 1982·Muscle & Nerve·R E Mrak
Feb 26, 2015·Journal of Neurology·Shinya MaeshimaGen Sobue
Dec 1, 1983·Journal of the Royal Society of Medicine·J Walton
Jun 14, 2006·Autoimmunity·C BrianiM C Dalakas
Jan 1, 1980·Acta Neuropathologica·S Matsubara

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