PMID: 3261680Sep 1, 1988Paper

Granulomatous Pneumocystis carinii pneumonia in three patients with the acquired immune deficiency syndrome

Chest
I J BleiweissJ A Strauchen

Abstract

Pneumocystis carinii pneumonia is a frequent manifestation of the acquired immune deficiency syndrome (AIDS). It usually presents radiologically as diffuse bilateral infiltrates and histologically as a foamy, eosinophilic intra-alveolar exudate containing the organisms' cysts. We recently studied two rare cases of P carinii pneumonia presenting as pulmonary nodules on chest x-ray films in two patients with AIDS. The corresponding histologies were a combination of the usual intra-alveolar pattern, with an alveolar and interstitial granulomatous appearance. Pneumocystis carinii was present in both areas and was the only organism found in the tissues examined. A third case presented with the more common radiographic appearance but also had a granulomatous histology. We conclude that P carinii pneumonia should be considered in the differential diagnosis of pulmonary nodules in immunocompromised patients and that pathologists should be aware of the possibility of a granulomatous reaction to this organism.

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Citations

Jan 1, 1991·International Journal of Antimicrobial Agents·I Varthalitis, F Meunier
Jun 1, 1990·The American Review of Respiratory Disease·J F Murray, J Mills
Sep 1, 1993·Chest·K WassermannG R Krueger
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Oct 23, 2002·Pathology, Research and Practice·Anthony A GalKamal A Mansour
Jul 1, 1990·Chest·F CapronE Maury
Aug 18, 2018·International Journal of STD & AIDS·Abdalsamih M TaebMichael H Hooper
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Dec 1, 1996·Clinics in Chest Medicine·S J Levine

Related Concepts

Acquired Immunodeficiency Syndrome
Granuloma
Lung
Pneumocystis Jiroveci Pneumonia
Tomography, X-Ray Computerized Axial

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