Granulomatous reaction in hepatic inflammatory angiomyolipoma after chemoembolization and spontaneous rupture

World Journal of Gastroenterology : WJG
Keita KaiHirokazu Noshiro

Abstract

A 77-year-old Japanese woman was transported to a nearby hospital due to sudden abdominal pain and transient loss of consciousness. Abdominal computed tomography (CT) suggested hemoperitoneum and hepatic nodule. She was conservatively treated. Contrast-enhanced CT two months later revealed an increased mass size, and the enhancement pattern suggested the possibility of hepatocellular carcinoma (HCC). Under a clinical diagnosis of HCC, transcatheter arterial chemoembolization (TACE) was performed. A subsequent imaging study revealed that most of the lipiodol used for the embolization was washed out. Therefore, surgical resection was performed. Histologically, the nodule contained numerous inflammatory cells including small lymphocytes, plasma cells and macrophages. Notably, epithelioid granulomatous features with multinucleated giant cells were observed in both the nodule and background liver. Some of the multinucleated giant cells contained oil lipid. Among the infiltrating inflammatory cells, spindle-shaped, histiocytoid or myoid tumor cells with eosinophilic cytoplasm were found. The tumor cells were positive for Melan A and HMB45. The nodule contained many IgG4-positive plasma cells; these were counted and found to number 72...Continue Reading

References

Mar 1, 1996·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Y ShigetakaT Yoshihiro
Jan 1, 1996·Langenbecks Archiv für Chirurgie·C HuberV Schumpelick
Jan 15, 1999·The American Journal of Surgical Pathology·W M TsuiA P Dhillon
Jan 15, 2005·Pathology, Research and Practice·Masaru KojimaNobuhide Masawa
Dec 15, 2007·Virchows Archiv : an International Journal of Pathology·Guido MartignoniFranco Bonetti
Feb 2, 2011·Journal of Surgical Oncology·Guang-Hui DingWen-Ming Cong
May 19, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Vikram DeshpandeJohn H Stone
Sep 18, 2012·Diagnostic Pathology·Yang LiuEn-Hua Wang
Jul 6, 2014·Case Reports in Oncology·Shogo TajimaKiyoshi Suzumura

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Citations

Apr 30, 2017·Clinical and Molecular Hepatology·Sun Hwa KimDong Hyun Sinn
May 28, 2021·World Journal of Gastroenterology : WJG·Paul CalameThierry Thévenot

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