PMID: 9192413May 1, 1997Paper

Granulomatous slack skin in childhood

Pediatric Dermatology
F M CamachoJ L Villar

Abstract

Granulomatous slack skin is an uncommon cutaneous T-helper cell lymphoma closely related to mycosis fungoides. To the best of our knowledge this disease has not been previously described in children. We report on an 11-year-old boy who presented with painless slack skin masses in the neck, right axilla and arm, anterior wall of the abdomen, both inguinal regions, and the malleolar and dorsal aspects of the feet. The disease started 3 years earlier with erythematous lesions on the neck and wrists. Histologic examination of a specimen from the abdominal mass revealed an extensive lymphoid infiltrate with scattered multinucleated giant cells extending from the papillary dermis to the subcutis. The lymphoid cells showed the following immunophenotype: CD43+ (MT1), CD45+, CD45RO+, CD20-. The phenotype of the giant cells was lysozyme positive, CD68+ and Mac387-. The tumoral lymphoid cells had clonal rearrangement for the gene of the beta chain of the T-cell receptor (C beta TCR). The disease could be controlled with systemic glucocorticoids. Due to the presence of many histiocytes arranged in aggregates in the papillary and mid-dermis, this case was initially considered to be a cutaneous form of histiocytosis. We recommend deep and ex...Continue Reading

References

Feb 1, 1992·The British Journal of Dermatology·K F HelmR K Winkelmann
Dec 1, 1995·Journal of the American Academy of Dermatology·R DeGregorioL F Glass
Jul 1, 1994·Histopathology·W Y TsangA W Lee

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Citations

Feb 9, 2006·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhixiang LiuJiawen Li
Jan 17, 2004·Journal of the American Academy of Dermatology·Joseph Gadzia, Thelda Kestenbaum
Nov 11, 1999·Current Opinion in Pediatrics·M T Hoang, S F Friedlander
Oct 4, 2006·Pediatric Dermatology·N OnsunN Büyükbabani
Nov 27, 2007·Pediatric Dermatology·J C Moreno-GiménezF M Camacho
Mar 30, 2011·Pediatric Blood & Cancer·Olivia BoccaraSylvie Fraitag
Dec 20, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·K D YazganogluC Baykal
Sep 30, 2014·Journal of the American Academy of Dermatology·Scarlett BoulosMadeleine Duvic
Feb 27, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·W KempfK Kerl
Jan 12, 2007·International Journal of Dermatology·María Rodríguez-VázquezJesús González-García
Nov 5, 2005·Pediatric Transplantation·Rolf G BennhagenErkki Pesonen
Jun 16, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·D V KazakovW Kempf
Oct 6, 2004·Pediatric Dermatology·Regina Fink-PuchesLorenzo Cerroni
Sep 1, 1999·Seminars in Cutaneous Medicine and Surgery·M C Garzon
Apr 3, 2018·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Alejandro A Gru, Louis P Dehner
Apr 17, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Iris Wohlmuth-Wieser

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