PMID: 6515324Nov 1, 1984Paper

Granulopoietic precursors in chronic neutropenia

Scandinavian Journal of Haematology
E NiskanenC E Hess

Abstract

11 patients with chronic neutropenia were evaluated. In 6 patients low numbers of CFU-DG were observed. Only 3 of these patients also had low CFU-C numbers, suggesting that these two precursors are not identical. Bone marrow samples from 2 patients were restudied a year later. The number of CFU-DG remained low while CFU-C numbers increased to control range in 1 patient. Studies for serum inhibitors were negative. No cytogenetic abnormalities were observed. This study suggests that abnormalities at different levels in the haemopoietic precursor cell hierarchy can be detected either simultaneously or independently in patients with chronic neutropenia.

References

Jan 1, 1979·American Journal of Hematology·E NiskanenM J Cline
Mar 1, 1979·Medicine·D C DaleM J Chusid
Nov 1, 1972·The Journal of Clinical Investigation·D W Golde, M J Cline
Aug 1, 1971·The Journal of Clinical Investigation·C R BishopJ W Athens
Aug 1, 1982·Annals of Internal Medicine·L Rosenstock
Oct 15, 1982·Science·L Tomatis
Feb 1, 1980·The American Journal of Medicine·J T Dancey, L H Brubaker
Feb 1, 1980·The Journal of Clinical Investigation·E Niskanen, M J Cline

Related Concepts

Agranulocytosis
Bone Marrow Cells
Colony-Forming Units Assay
Granulocyte
Hematopoiesis, Medullary
Differential White Blood Cell Count Procedure
Neutropenia
Colony-forming Unit

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