Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity

Seminars in Immunology
S V Peña, A M Krensky

Abstract

A primary process by which cytotoxic T lymphocytes (CTL) and natural killer (NK) cells lyse target cells involves the regulated exocytosis of granules present in the cytoplasm of the effector. These granules contain proteins, such as perforin and the granzymes, that play a direct role in the killing process. The localization of a human T and NK cell-specific protein, granulysin (formerly 519), to cytolytic granules suggests that additional mechanisms may be involved in granule-mediated cytolysis. This protein shares homology with small, granule-associated molecules and is a member of a larger family of proteins known as saposin-like proteins (SAPLIP). SAPLIP share common structural features allowing for association with lipids while retaining the ability to mediate a variety of different functions. Expression of granulysin is induced late after T-cell activation, similar to perforin and the granzymes. Two prominent protein products of 15 and 9kDa were identified in CTL. The 9kDa form localizes to dense, highly cytolytic granules and contains the SAPLIP homology domain. A recombinant granulysin protein, corresponding to the 9kDa form, is cytolytic against tumor cell targets.

Citations

Mar 19, 2002·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mitsuaki SekiyaYoshinosuke Fukuchi
Mar 4, 2008·The Journal of Antimicrobial Chemotherapy·Ana Paula Galvão da SilvaCarol Clayberger
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Qing LiAlan M Krensky
Apr 20, 2006·Infection and Immunity·Michael T BorchersGee W Lau
Sep 19, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·K IkezoeJ-i Kira
Jun 8, 1999·Annual Review of Immunology·S A Porcelli, R L Modlin
May 16, 2014·Pharmaceuticals·Guangshun Wang
Nov 10, 2007·Clinical Reviews in Allergy & Immunology·Heidi GoodarziRichard L Gallo
Mar 12, 2005·Journal of the American Academy of Dermatology·Arash Izadpanah, Richard L Gallo
Feb 15, 2001·Expert Opinion on Investigational Drugs·J KumarA M Krensky
Feb 13, 2013·Journal of Reproductive Immunology·Danijela Veljkovic VujaklijaDaniel Rukavina
Feb 27, 2009·Leukemia Research·Noriko KitamuraNobutaka Kiyokawa
Nov 14, 2006·Immunology Letters·Marcus LettauOttmar Janssen
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alan M Krensky, Carol Clayberger
Mar 20, 2004·Clinical and Experimental Immunology·M SakaiS Saito
Mar 4, 2009·Tissue Antigens·A M Krensky, C Clayberger
Jun 9, 2007·Biochimica Et Biophysica Acta·Xi ChenKlaus Brandenburg
Jan 3, 2006·Veterinary Immunology and Immunopathology·Yeong Ho HongErik P Lillehoj
Jan 15, 2002·Cardiology Clinics·F G Blankenberg, H W Strauss
Mar 10, 2016·Journal of Biomolecular Structure & Dynamics·Haitham A YacoubVladimir N Uversky
Jan 21, 2015·International Journal of Dermatology·Hee-Sun LimSeong-Jin Kim
Mar 24, 2007·Tuberculosis·Diana Di LibertoAlfredo Salerno
Dec 19, 2002·Journal of Molecular Biology·Daniel H AndersonDavid Eisenberg
Jul 12, 2005·Fish & Shellfish Immunology·Qun WangZhanjiang Liu
Nov 18, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezGerard Tromp
Apr 28, 2000·International Immunology·L Mincheva-NilssonV Baranov
Mar 3, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jing CuiJoan Burnside

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.