Granulysin, a novel marker for extranodal NK/T cell lymphoma, nasal type

Virchows Archiv : an International Journal of Pathology
Giuseppe Lo BelloTeresa Marafioti

Abstract

Granulysin is a cytolytic protein expressed in cytotoxic T and natural killer (NK) cells. Abnormal serum levels of granulysin in lymphomas with NK and cytotoxic phenotype have been shown to correlate with tumour progression. In this study, we investigated the expression pattern of granulysin in routine sections of normal and reactive lymphoid tissues as well as in a large series of lymphomas. In normal tissues, granulysin labelled a small population of cells that double immunostaining revealed to belong to the pool of cytotoxic T/NK cells. Among lymphoid neoplasms, the highest expression of granulysin (71%) was found in extranodal NK/T cell lymphomas of nasal type (ENKTL). To note is that 29% of ENKTLs, which were negative for one or more of classical cytotoxic markers strongly expressed granulysin. Furthermore, expression of granulysin was observed in rare cases of T cell lymphomas with a cytotoxic phenotype (i.e. ALK-negative anaplastic large cell lymphoma (26%), enteropathy-associated T cell lymphoma (12%) and peripheral T cell lymphoma, NOS (4%)). None of the investigated non-Hodgkin B cell lymphomas, Hodgkin lymphoma and plasma cell myeloma were granulysin positive. The results suggest granulysin as a novel marker for a su...Continue Reading

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Citations

Nov 20, 2018·Expert Review of Anticancer Therapy·Vadim S Pokrovsky, Denis Vinnikov
Feb 27, 2020·International Journal of Molecular Sciences·Atif Saleem, Yasodha Natkunam
May 30, 2020·International Journal of Molecular Sciences·Christian Sordo-BahamondeAlejandro López-Soto

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Methods Mentioned

BETA
PCR
biopsies

Software Mentioned

GraphPad

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