Granzyme B; the chalk-mark of a cytotoxic lymphocyte

Journal of Translational Medicine
Nigel J WaterhouseChris Jp Clarke


During cytotoxic lymphocyte (CL) mediated killing of target cells, granzyme B is released from the CL into the immune synapse. Recent studies have found that ELISPOT-detection of granzyme B correlated well with conventional assays for CL mediated killing. In this way, the released granzyme B can be used to mark the spot where a target cell was murdered. We discuss the benefits and potential limitations of using this assay to measure CL mediated killing of target cells.


Jan 1, 1992·European Journal of Immunology·S R BurrowsD J Moss
Aug 18, 1995·Journal of Immunological Methods·M Okano, D T Purtilo
Jul 20, 1999·Journal of Immunological Methods·M M RodenF M Marincola
Feb 24, 2000·The Journal of Experimental Medicine·M J SmythD I Godfrey
Jun 16, 2000·Journal of Immunological Methods·F H RininslandM Tary-Lehmann
Sep 7, 2000·The Journal of Experimental Medicine·M J SmythJ A Trapani
Mar 30, 2001·The Journal of Biological Chemistry·M J PinkoskiD R Green
Jun 21, 2002·Tissue Antigens·N J Waterhouse, J A Trapani
Oct 3, 2002·Nature Reviews. Immunology·Joseph A Trapani, Mark J Smyth
Oct 24, 2003·Apoptosis : an International Journal on Programmed Cell Death·K R JeromeM Aubert
Dec 31, 2003·Journal of Translational Medicine·Kimberly Shafer-WeaverAnatoli Malyguine
Jun 23, 2004·Microbes and Infection·Michelle E Wowk, Joseph A Trapani
Aug 18, 2004·Biochemical Pharmacology·Nigel J WaterhouseJoseph A Trapani
Sep 24, 2004·Journal of Translational Medicine·Kimberly A Shafer-WeaverAnatoli Malyguine

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