PMID: 25788270Mar 20, 2015Paper

Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation

Oncotarget
Huiru WangShuren Zhang

Abstract

Granzyme M is a serine protease known to be often expressed by natural killer cells and induce target cells apoptosis in combination with perforin. However, we detected granzyme M expression in murine and human cancer cell lines and human tumor samples in our study. Granzyme M increased chemoresistance, colony-formation, cytokine secretion and invasiveness in vitro. Most importantly, granzyme M facilitated tumor growth and metastasis in vivo. Granzyme M induced the epithelial-mesenchymal transition (EMT) in cancer cells associated with STAT3 activation. Our study revealed the role of granzyme M expressed by tumor in chemoresistance, invasion, metastasis and EMT.

Citations

Jun 29, 2016·Journal of Cancer Research and Clinical Oncology·Nobuhiro KanajiShuji Bandoh
Aug 25, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuan LiChangzhi Huang
Jul 22, 2016·Cell Death & Disease·F Souza-Fonseca-GuimaraesM J Smyth
Aug 30, 2017·International Journal of Molecular Sciences·Beatriz Martín-AntonioAlvaro Urbano-Ispizua
May 30, 2020·International Journal of Molecular Sciences·Christian Sordo-BahamondeAlejandro López-Soto

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