Grape seed proanthocyanidin extract improves the hepatic glutathione metabolism in obese Zucker rats

Molecular Nutrition & Food Research
Anabel Fernández-IglesiasMiquel Mulero

Abstract

Increased oxidative stress may play an important role in metabolic syndrome and related manifestations, including obesity, atherosclerosis, hypertension, and insulin resistance. Its relation to obesity is due to increased reactive oxygen species and/or decreased glutathione (GSH) antioxidant metabolism. Consequently, the activation of glutathione metabolism appears to be a central defense response to prevent oxidative stress. In this sense, dietary supplements with natural antioxidant molecules, including proanthocyanidins, may present a useful strategy of controlling and reducing complications of obesity, including hepatic steatosis. We assessed the grape seed proanthocyanidin extract (GSPE) effect on oxidative alterations related to genetically obese rats (Zucker rats) and, more specifically, to hepatic GSH metabolism. We demonstrate that the administration of GSPE reduced the oxidized glutathione accumulation increasing the total GSH/oxidized glutathione hepatic ratio and consequently decreasing the activation of antioxidant enzymes, including glutathione peroxidase, glutathione reductase, and glutathione S-transferase, and increasing the total antioxidant capacity of the cell. In Zucker rats, the obesity-induced oxidative s...Continue Reading

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Citations

Jan 23, 2016·Phytotherapy Research : PTR·Maryam Akaberi, Hosein Hosseinzadeh
Jan 17, 2015·Molecular Nutrition & Food Research·Isabel Cordero-HerreraSonia Ramos
Oct 27, 2015·Journal of Agricultural and Food Chemistry·Maria MargalefAnna Arola-Arnal
Jun 3, 2016·International Journal of Food Sciences and Nutrition·Weinan LiXiangjun Sun
Nov 4, 2016·Molecular Nutrition & Food Research·Maria MargalefBegoña Muguerza
Jun 5, 2019·Applied Microbiology and Biotechnology·Jin-Wei ZhouAi-Qun Jia
Oct 17, 2019·Nutrients·Celia Rodríguez-PérezVito Verardo
Mar 25, 2017·Frontiers in Pharmacology·Longyun ZhangHongwei Si
May 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Longyun ZhangHongwei Si

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