Grapefruit juice enhances the systolic blood pressure-lowering effects of dietary nitrate-containing beetroot juice.

British Journal of Clinical Pharmacology
Kevin O'GallagherAndrew J Webb

Abstract

Dietary nitrate from sources such as beetroot juice lowers blood pressure (BP) via the nitrate-nitrite-nitric oxide (NO) pathway. However, NO and nitrite are inactivated via reoxidation to nitrate, potentially limiting their activity. Cytochrome P450-3A4 inhibition with troleandomycin prevents nitrite re-oxidation to nitrate in rodent liver. Grapefruit juice contains the CYP3A4 inhibitor furanocoumarin. We therefore hypothesized that grapefruit juice would enhance BP-lowering with beetroot juice by maintaining circulating [nitrite]. We performed a randomized, placebo-controlled, 7-hour crossover study in 11 healthy volunteers, attending on 3 occasions, receiving: a 70-mL shot of active beetroot juice (Beet-It) and either (i) 250 mL grapefruit juice (Active Beet+GFJ), or (ii) 250 mL water (Buxton, Active Beet+H2 O); or (iii) Placebo Beet+GFJ. The addition of grapefruit juice to active beetroot juice lowered systolic BP (SBP): Active Beet+GFJ vs Active Beet+H2 O (P = .02), and pulse pressure, PP (P = .0003). Peak mean differences in SBP and PP were seen at T = 5 hours: -3.3 mmHg (95% confidence interval [CI] -6.43 to -0.15) and at T = 2.5 hours: -4.2 mmHg (95% CI -0.3 to -8.2), respectively. Contrary to the hypothesis, plasma [ni...Continue Reading

References

Oct 1, 1987·The Journal of Clinical Investigation·P B WatkinsP S Guzelian
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroR E Byrns
Sep 2, 1998·British Journal of Clinical Pharmacology·D G BaileyJ D Spence
Apr 18, 2001·Journal of Clinical Pharmacology·M J SheltonR DiFrancesco
Nov 5, 2003·Nature Medicine·Kenyatta CosbyMark T Gladwin
Feb 8, 2005·European Journal of Oral Sciences·Justin Johnston DoelRobert Patrick Allaker
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Laura J GrayPhilip M W Bath
Nov 22, 2011·Antioxidants & Redox Signaling·Erin CurtisSruti Shiva
Jun 23, 2012·Free Radical Biology & Medicine·Lucas C PinheiroJose E Tanus-Santos
Jul 31, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Almudena PerezFrancisco Perez-Vizcaino
Jan 30, 2016·Journal of the American College of Cardiology·Senthil SelvarajUNKNOWN REACH Registry Investigators
Sep 25, 2017·Journal of the American College of Cardiology·Charlotte E MillsJ Kennedy Cruickshank
Dec 5, 2017·Nitric Oxide : Biology and Chemistry·Luke LiddleChris Easton
Jan 20, 2018·Journal of the American College of Cardiology·Kevin O'GallagherAndrew J Webb
Feb 1, 2018·Current Pharmaceutical Design·Rosaria Vincenza GiglioMaciej Banach
Jan 24, 2019·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Arrigo F G CiceroClaudio Ferri

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