Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder

Journal of Affective Disorders
Casey C ArmstrongJoseph O'Neill

Abstract

fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD. Whole-brain resting-state fMRI was acquired at 3T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 child-based functional nodes. We also compared local metrics between groups in frontopolar, supplementary motor, and sensorimotor cortices, regions implicated in recent neuroimaging and/or brain stimulation treatment studies in OCD. As in adults, the global metric small-worldness was significantly (P<0.05) lower in patients than controls, by 13.5% (%mean difference=100%X(OCD mean - control mean)/control mean). This suggests less efficient information transfer in patients. In addition, modularity was lower in OCD (15.1%, P<0.01), suggesting less granular - or differently organized - functional brain parcellation. Higher clustering coefficients (23.9-32.4%, P<0.05) were observed in patients in frontopolar, supplementary motor, sensorimotor, and cortices with lower betweenness centrality (-63.6%, P<0.01) at one frontopolar site. These findings are consistent with more locally intensive connectivity or less interaction with other brain r...Continue Reading

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Citations

Jan 10, 2019·Psychological Medicine·Daniel GeislerStefan Ehrlich
Jan 18, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marilyn CyrRachel Marsh
Jun 30, 2019·Frontiers in Neuroscience·Farzad V FarahaniNichole R Lighthall
Feb 2, 2021·Human Brain Mapping·Lekai LuoQiyong Gong
Aug 11, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Aaron F Alexander-BlochRan Barzilay

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