Graph Theoretical Framework of Brain Networks in Multiple Sclerosis: A Review of Concepts

Neuroscience
Vinzenz FleischerSergiu Groppa

Abstract

Network science provides powerful access to essential organizational principles of the human brain. It has been applied in combination with graph theory to characterize brain connectivity patterns. In multiple sclerosis (MS), analysis of the brain networks derived from either structural or functional imaging provides new insights into pathological processes within the gray and white matter. Beyond focal lesions and diffuse tissue damage, network connectivity patterns could be important for closely tracking and predicting the disease course. In this review, we describe concepts of graph theory, highlight novel issues of tissue reorganization in acute and chronic neuroinflammation and address pitfalls with regard to network analysis in MS patients. We further provide an outline of functional and structural connectivity patterns observed in MS, spanning from disconnection and disruption on one hand to adaptation and compensation on the other. Moreover, we link network changes and their relation to clinical disability based on the current literature. Finally, we discuss the perspective of network science in MS for future research and postulate its role in the clinical framework.

Citations

Nov 28, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Ismail KoubiyrAurélie Ruet
Sep 11, 2019·Brain : a Journal of Neurology·Ismail KoubiyrAurélie Ruet
Feb 7, 2020·Human Brain Mapping·Angela RadetzSergiu Groppa
Feb 7, 2020·Neurology. Neuroimmunology and Neuroinflammation·Muthuraman MuthuramanSergiu Groppa
May 29, 2018·Nature Reviews. Neurology·Annemieke Ter TelgteFrank-Erik de Leeuw
Oct 27, 2018·Frontiers in Neurology·Marlene TahedlJens V Schwarzbach
Jun 30, 2019·Frontiers in Neuroscience·Farzad V FarahaniNichole R Lighthall
Apr 20, 2018·Behavioral Sciences·Karla Batista-García-Ramó, Caridad Ivette Fernández-Verdecia
Feb 26, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Carmen TurOlga Ciccarelli
Mar 4, 2020·Neurology. Neuroimmunology and Neuroinflammation·Yael BacknerNetta Levin
Jun 14, 2020·Journal of Neuroinflammation·Manuela CerinaSven G Meuth
Apr 17, 2019·Nature Reviews. Neurology·Katrin PapeFrauke Zipp
Dec 28, 2019·International Journal of Molecular Sciences·Mario Stampanoni BassiFabio Buttari
Apr 8, 2020·Annals of Clinical and Translational Neurology·Gabriel Gonzalez-EscamillaSergiu Groppa
Sep 6, 2019·International Journal of Molecular Sciences·Vo Van GiauSang Yun Kim
Nov 5, 2019·Frontiers in Neuroscience·Farzad V FarahaniTadeusz Marek
Dec 7, 2018·Frontiers in Psychiatry·Gabriel Gonzalez-EscamillaSergiu Groppa
Oct 10, 2020·Brain Circulation·Hayder M Al-KuraishyAli I Al-Gareeb
Dec 10, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Ilse M NautaMenno M Schoonheim
Jul 18, 2020·Medical Hypotheses·Abdorreza Naser Moghadasi
Mar 5, 2021·The Journal of Headache and Pain·Lars MichelsMuthuraman Muthuraman
Apr 20, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Menno M SchoonheimJeroen Jg Geurts
Jul 3, 2021·Brain Connectivity·Sara BosticardoCristina Granziera
Sep 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Vinzenz FleischerSergiu Groppa
Sep 30, 2021·Neurorehabilitation and Neural Repair·Roger M EnokaJacques Duchateau
Oct 30, 2021·Frontiers in Immunology·Angela RadetzSergiu Groppa
Dec 31, 2021·Annals of Neurology·Vinzenz FleischerUNKNOWN German Competence Network Multiple Sclerosis (KKNMS)

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