Graph theory approaches to functional network organization in brain disorders: A critique for a brave new small-world

Network Neuroscience
Michael N Hallquist, Frank G Hillary

Abstract

Over the past two decades, resting-state functional connectivity (RSFC) methods have provided new insights into the network organization of the human brain. Studies of brain disorders such as Alzheimer's disease or depression have adapted tools from graph theory to characterize differences between healthy and patient populations. Here, we conducted a review of clinical network neuroscience, summarizing methodological details from 106 RSFC studies. Although this approach is prevalent and promising, our review identified four challenges. First, the composition of networks varied remarkably in terms of region parcellation and edge definition, which are fundamental to graph analyses. Second, many studies equated the number of connections across graphs, but this is conceptually problematic in clinical populations and may induce spurious group differences. Third, few graph metrics were reported in common, precluding meta-analyses. Fourth, some studies tested hypotheses at one level of the graph without a clear neurobiological rationale or considering how findings at one level (e.g., global topology) are contextualized by another (e.g., modular structure). Based on these themes, we conducted network simulations to demonstrate the impa...Continue Reading

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Citations

Jul 10, 2019·The International Journal of Neuropsychopharmacology·Emeline MullierPatric Hagmann
Aug 23, 2019·Neurorehabilitation and Neural Repair·Kihwan HanDaniel C Krawczyk
Mar 13, 2020·Human Brain Mapping·Zhen ZhouDinggang Shen
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Feb 10, 2021·Cerebral Cortex·Josepheen De Asis-CruzCatherine Limperopoulos
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Mar 11, 2021·Network Neuroscience·Andrea I Luppi, Emmanuel A Stamatakis
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Aug 28, 2021·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jaclyn S KirshenbaumIan H Gotlib

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