Graphene-based platforms for cancer therapeutics

Therapeutic Delivery
Sunny C PatelBalaji Sitharaman

Abstract

Graphene is a multifunctional carbon nanomaterial and could be utilized to develop platform technologies for cancer therapies. Its surface can be covalently and noncovalently functionalized with anticancer drugs and functional groups that target cancer cells and tissue to improve treatment efficacies. Furthermore, its physicochemical properties can be harnessed to facilitate stimulus responsive therapeutics and drug delivery. This review article summarizes the recent literature specifically focused on development of graphene technologies to treat cancer. We will focus on advances at the interface of graphene based drug/gene delivery, photothermal/photodynamic therapy and combinations of these techniques. We also discuss the current understanding in cytocompatibility and biocompatibility issues related to graphene formulations and their implications pertinent to clinical cancer management.

References

Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P L FelgnerM Danielsen
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·J L RavanatJ Cadet
Sep 10, 2005·Nature Biotechnology·Anna M Wu, Peter D Senter
Jul 13, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hongtao LvJie Yan
Aug 15, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tracy R DanielsManuel L Penichet
Mar 3, 2007·Nature·Jannik C MeyerS Roth
Mar 3, 2007·Nature Materials·A K Geim, K S Novoselov
Jan 15, 2008·Urologic Oncology·Barbara Haley, Eugene Frenkel
Jan 15, 2008·Urologic Oncology·Frank AlexisOmid C Farokhzad
Jul 30, 2008·Journal of the American Chemical Society·Zhuang LiuHongjie Dai
Sep 2, 2008·Nature Reviews. Drug Discovery·Mark E DavisDong M Shin
Jun 23, 2009·Science·A K Geim
Jul 1, 2009·Nature Reviews. Nephrology·Vaibhav SahniZiauddin Ahmed
Jul 21, 2009·Chemical Reviews·Matthew J AllenRichard B Kaner
Oct 8, 2009·Nature Nanotechnology·Michael Segal
Nov 10, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pakatip RuenraroengsakAlexander T Florence
Jan 1, 2008·Nano Research·Xiaoming SunHongjie Dai
Jul 8, 2010·Journal of Neuro-oncology·Soon-Tae LeeJae-Kyu Roh
Aug 14, 2010·Pharmacology & Therapeutics·Dhruba J Bharali, Shaker A Mousa
Jan 13, 2011·Pharmaceutical Research·Francisco C Pérez-MartínezValentín Ceña
Jan 29, 2011·Nanoscale·Liangzhu FengZhuang Liu
Mar 10, 2011·Nanomedicine·Liangzhu Feng, Zhuang Liu
Mar 15, 2011·Trends in Biotechnology·Ying WangYuehe Lin
Apr 12, 2011·Journal of the American Chemical Society·Joshua T RobinsonHongjie Dai
Sep 15, 2011·Chemistry : a European Journal·Lin ZhouJian Shen
Mar 21, 2012·Nano Letters·Yantao ChenRobert H Hurt
Mar 27, 2012·Theranostics·He ShenZhijun Zhang
Jun 2, 2012·Nanoscale·Yin ZhangWeibo Cai
Jun 16, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelElizabeth Ward
Jul 4, 2012·International Journal of Endocrinology·Sana SiddiquiStuart Maudsley
Oct 13, 2012·Chemical Society Reviews·Kai YangZhuang Liu
Oct 18, 2012·Biomaterials·Sayan Mullick ChowdhuryBalaji Sitharaman
Nov 7, 2012·Journal of Biochemical and Molecular Toxicology·Ramakrishna Podila, Jared M Brown

❮ Previous
Next ❯

Citations

Apr 15, 2016·Therapeutic Delivery·Okhil K NagJames B Delehanty
May 29, 2016·Advanced Drug Delivery Reviews·Kai YangZhuang Liu
Jul 3, 2016·Drug Discovery Today·Maria Chatzinikolaidou
Aug 17, 2016·Journal of Biomedical Materials Research. Part a·Gaurav LalwaniBalaji Sitharaman
Aug 30, 2016·Advanced Drug Delivery Reviews·Bo ZhangTaotao Wei
Dec 30, 2016·ACS Applied Materials & Interfaces·Yin-Jia ChengXian-Zheng Zhang
Mar 16, 2017·Journal of Biomedical Materials Research. Part a·Gaurav LalwaniBalaji Sitharaman
Jan 6, 2017·Nanoscale·Mauricio D Rojas-AndradeShaowei Chen
Jun 15, 2018·Advanced Materials·Zhaoxu TuRainer Haag
Jul 25, 2018·Advanced Materials·Zhanjun GuYuliang Zhao
Oct 18, 2018·Chemistry : a European Journal·Bang-Ping JiangXing-Can Shen
Jan 13, 2019·Journal of Biomedical Materials Research. Part a·Behzad FarshidBalaji Sitharaman
Apr 30, 2016·Annals of Biomedical Engineering·Gaurav LalwaniBalaji Sitharaman
Sep 20, 2019·Journal of Experimental & Clinical Cancer Research : CR·Mao XiaJiwu Wei
Mar 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Linji GongZhanjun Gu
Mar 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hui-Chen Chang ForemanBalaji Sitharaman
Aug 8, 2020·International Journal of Molecular Sciences·Valeria VerdeDiego La Mendola
Mar 27, 2020·International Journal of Nanomedicine·Lingling OuLongquan Shao
Oct 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marisa ColoneAnnarita Stringaro
Feb 6, 2021·Drug Delivery and Translational Research·Yujie CaiZhen Gu
Apr 4, 2021·International Journal of Molecular Sciences·Banendu Sunder DashJyh-Ping Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
xenografts
transfect
fluorescence imaging
xenograft
nuclear translocation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.