Graphene for the development of the next-generation of biocomposites for dental and medical applications

Dental Materials : Official Publication of the Academy of Dental Materials
Han XieVinicius Rosa

Abstract

Graphene and its derivatives, graphene oxide (GO) and reduced graphene oxide (rGO), are 2D carbon-based materials with remarkable physical, chemical and biological properties. Graphene sheets have high specific surface area and mechanical strength. Moreover, they have been shown to influence the differentiation of stem cells and to improve properties of biomaterials. Here, we present the recent achievements on the use of graphene and its derivatives to improve properties and enhance bioactivity of biomaterials. We also discuss the biosafety constraints to be solved to translate these carbonaceous materials to the clinic. Graphene and its derivatives can be functionalized and further modified with several bioactive molecules. They can be combined with several biomaterials used in regenerative and reconstructive dentistry and medicine. The resultant graphene-modified composites often present improved physico-mechanical properties and enhanced bioactivity. Moreover, graphene-modified composites are promising candidates to deliver growth factors, drugs and others bioactive compounds. Graphene can improve the physical, chemical and mechanical properties of biomaterials. As it can be functionalized and combined with several biomolecu...Continue Reading

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Citations

Apr 4, 2018·Journal of Biomedical Materials Research. Part a·Dorsa MohammadrezaeiLobat Tayebi
Mar 6, 2018·Advanced Healthcare Materials·Hüseyin Enis KarahanYuan Chen
Dec 12, 2019·European Journal of Oral Sciences·Aftab A KhanElzahraa Eldwakhly
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Feb 1, 2019·International Journal of Molecular Sciences·Han XieVinicius Rosa
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Sep 11, 2020·Nanomaterials·Victoria Bonilla-RepresaM Olga Guerrero-Pérez
Nov 27, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Daniela DiasNatália M Alves
Dec 29, 2020·Dental Materials : Official Publication of the Academy of Dental Materials·Shruti Vidhawan AgarwallaVinicius Rosa
Mar 27, 2021·Drug Delivery and Translational Research·Sevda ŞenelGülçin Akca
Jul 14, 2021·Journal of Dental Research·V RosaA H Castro Neto
Sep 2, 2021·Dental Materials : Official Publication of the Academy of Dental Materials·Wendy ChenQuan-Li Li

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